Salt-Responsive Gut Microbiota Induces Sex-Specific Blood Pressure Changes
We uncovered a novel sex-specific mechanism in the gut microbiota-mediated tryptophan-indole pathway in blood pressure regulation. Salt tipped the tryptophan metabolism between the host and gut microbiota in a sex-dependent manner. Our study provides evidence for a novel concept that gut microbiota and its metabolism play sex-specific roles in the development of salt-sensitive hypertension.
Authors
- Pritam Bardhan (ORCID: https://orcid.org/0000-0003-0091-3080)
- Ishan Manandhar (ORCID: https://orcid.org/0000-0001-6772-2540)
- Bina Joe (ORCID: https://orcid.org/0000-0002-2385-7061)
- Blair Mell (ORCID: https://orcid.org/0000-0002-1224-4948)
- Tao Yang (ORCID: https://orcid.org/0000-0002-4182-9793)
- Jun Kyoung (ORCID: https://orcid.org/0000-0001-5403-460X)
- Nicole T Lai
- Sachin Aryal (ORCID: https://orcid.org/0000-0002-1939-6338)
- Ramakumar Tummala (ORCID: https://orcid.org/0000-0002-3887-3566)
- Xue Mei (ORCID: https://orcid.org/0000-0001-7547-5746)
- Rohit Atluri
- Ying Li (ORCID: https://orcid.org/0000-0002-9042-4768)
- Hong‐Bao Li (ORCID: https://orcid.org/0000-0002-1600-9590)
- Hyun Seok Hwang (ORCID: https://orcid.org/0000-0001-6777-3073)
- Tania Akter Jhuma
Institutions
- North Sichuan Medical University (CN)
- Xi'an Jiaotong University (CN)
- University of Toledo (US)
Publication Details
- Journal
- Circulation Research
- Published
- 2024-10-23
- DOI
- https://doi.org/10.1161/circresaha.124.325056
- Citations
- 24
- Primary Topic
- Tryptophan and brain disorders
- Type
- article
- Field-Weighted Citation Impact
- 3.78
Funders
- American Heart Association
- National Natural Science Foundation of China