In Silico Modeling of Myelin Oligodendrocyte Glycoprotein Disulfide Bond Reduction by Phosphine-Borane Complexes
These findings suggest that PBs can affect the structure of MOG dimers and the formation of antibody complexes by reducing the MOG disulfide bond. Structural changes in MOG could have implications for neurodegenerative diseases and anti-MOG syndrome.
Authors
- Raheem Remtulla
- Leonard A. Levin (ORCID: https://orcid.org/0000-0002-1399-250X)
- Sanjoy Das (ORCID: https://orcid.org/0000-0001-6589-9967)
Institutions
- McGill University Health Centre (CA)
- McGill University (CA)
Publication Details
- Journal
- Pharmaceuticals
- Published
- 2024-10-23
- DOI
- https://doi.org/10.3390/ph17111417
- Primary Topic
- Biochemical effects in animals
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- McGill University
- McGill University Health Centre
- Canada Research Chairs
- Santen
- Genentech
- Canadian Institutes of Health Research