Increased TRPV4 Channel Expression Enhances and Impairs Blood Vessel Function in Hypertension
These data highlight the intricate interplay between endothelial TRPV4 channel expression, intracellular Ca<sup>2+</sup> signaling dynamics, and vascular reactivity. Moreover, the data support a new unifying hypothesis for the vascular impairment that accompanies hypertension. Specifically, endothelial cell TRPV4 channels play a dual role in modulating blood vessel function in hypertension.
Authors
- John G. McCarron (ORCID: https://orcid.org/0000-0002-3302-3984)
- Matthew D. Lee (ORCID: https://orcid.org/0000-0001-8265-382X)
- Christine Salaün (ORCID: https://orcid.org/0000-0003-3002-6810)
- Calum Wilson (ORCID: https://orcid.org/0000-0003-2500-0632)
- Charlotte Buckley (ORCID: https://orcid.org/0000-0002-7961-4544)
- Xun Zhang (ORCID: https://orcid.org/0000-0003-0790-4291)
- Margaret MacDonald
Institutions
- University of Strathclyde (GB)
Publication Details
- Journal
- Hypertension
- Published
- 2024-10-23
- DOI
- https://doi.org/10.1161/hypertensionaha.124.23092
- Citations
- 11
- Primary Topic
- Sodium Intake and Health
- Type
- article
- Field-Weighted Citation Impact
- 3.41
Funders
- British Heart Foundation