The deficient CLEC5A ameliorates the behavioral and pathological deficits via the microglial Aβ clearance in Alzheimer’s disease mouse model
The Clec5a knockout ameliorates AD-like deficits by modulating microglial Aβ clearance. This study implies that targeting microglial Clec5a could offer a promising approach to mitigate AD progression.
Authors
- Wen‐Han Chang (ORCID: https://orcid.org/0000-0002-2071-7258)
- Irene Han‐Juo Cheng (ORCID: https://orcid.org/0000-0002-3737-3877)
- Shie‐Liang Hsieh (ORCID: https://orcid.org/0000-0001-9415-346X)
- Yu-Yi Lin (ORCID: https://orcid.org/0000-0003-4452-7501)
Institutions
- National Yang Ming Chiao Tung University (TW)
- National Health Research Institutes (TW)
- Taipei Veterans General Hospital (TW)
Publication Details
- Journal
- Journal of Neuroinflammation
- Published
- 2024-10-23
- DOI
- https://doi.org/10.1186/s12974-024-03253-x
- Citations
- 6
- Primary Topic
- Neuroinflammation and Neurodegeneration Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 1.48
Funders
- Academia Sinica
- Shanghai Educational Development Foundation
- Ministry of Education, India
- National Health Research Institutes
- National Science and Technology Council