Senescent Syncytiotrophoblast Secretion During Early Onset Preeclampsia
This indicates that increased syncytiotrophoblast senescence appears weeks before clinical manifestation of early onset preeclampsia, suggesting that the dysregulated preeclamptic placenta starts with higher cell maturation resulting in premature and increased senescence-associated secretory phenotype release. These senescence-associated secretory phenotype markers may serve as an additional early diagnostic tool for this syndrome.
Authors
- Jose Nimo (ORCID: https://orcid.org/0000-0002-1565-7799)
- Sandra Haider (ORCID: https://orcid.org/0000-0003-2409-1317)
- Cornelius Fischer (ORCID: https://orcid.org/0000-0003-0329-2435)
- Nadine Haase (ORCID: https://orcid.org/0000-0003-0727-1738)
- Meryam Sugulle (ORCID: https://orcid.org/0000-0003-4160-3978)
- Olivia Debnath (ORCID: https://orcid.org/0009-0009-2845-055X)
- Katja Sallinger (ORCID: https://orcid.org/0000-0003-1130-2314)
- Martin Gauster (ORCID: https://orcid.org/0000-0003-0386-6857)
- Martin Knöfler (ORCID: https://orcid.org/0000-0001-6625-8950)
- Alexander Malt
- Berthold Huppertz (ORCID: https://orcid.org/0000-0003-4814-2158)
- Sarah Kedziora (ORCID: https://orcid.org/0000-0003-0124-2557)
- Daniela S. Valdes (ORCID: https://orcid.org/0000-0002-1309-5147)
- Kristin Kräker (ORCID: https://orcid.org/0000-0002-4032-5382)
- B. Thilaganathan (ORCID: https://orcid.org/0000-0002-5531-4301)
- Christina Stern (ORCID: https://orcid.org/0000-0002-6330-1236)
- Thomas Kuenzer (ORCID: https://orcid.org/0000-0001-6882-1217)
- Thomas Kroneis (ORCID: https://orcid.org/0000-0002-4761-9340)
- Philipp Mensing (ORCID: https://orcid.org/0000-0001-6590-1975)
- Stephen Tong (ORCID: https://orcid.org/0000-0002-2319-0586)
- Roland Eils (ORCID: https://orcid.org/0000-0002-0034-4036)
- Florian Herse (ORCID: https://orcid.org/0000-0002-9305-8134)
- Olivia Nonn (ORCID: https://orcid.org/0000-0001-6385-2866)
- Naveed Ishaque (ORCID: https://orcid.org/0000-0002-8426-901X)
- Stefan Verlohren (ORCID: https://orcid.org/0000-0003-3507-8636)
- Anne Cathrine Staff (ORCID: https://orcid.org/0000-0001-9247-5721)
- Stuart Jones (ORCID: https://orcid.org/0000-0002-3106-6155)
- Sebastian Tiesmeyer (ORCID: https://orcid.org/0000-0002-0492-1523)
- Alina Frolova (ORCID: https://orcid.org/0000-0001-5469-7366)
- Ruth Schmidt‐Ullrich (ORCID: https://orcid.org/0000-0002-2472-6530)
- Hendrik Bartolomaeus (ORCID: https://orcid.org/0000-0003-4288-3828)
- Désirée Forstner (ORCID: https://orcid.org/0000-0001-5451-7580)
- Kerim Secener (ORCID: https://orcid.org/0000-0003-4806-2852)
- Niklas Müller‐Bötticher (ORCID: https://orcid.org/0000-0001-5103-7282)
- Ralf Dechend (ORCID: https://orcid.org/0000-0001-6636-3080)
- Lena Neuper
- Amin El‐Heliebi (ORCID: https://orcid.org/0000-0002-7679-6856)
- Dominik N. Müller (ORCID: https://orcid.org/0000-0003-3650-5644)
- Tu’uhevaha J. Kaitu’u‐Lino (ORCID: https://orcid.org/0000-0001-6233-9737)
- Theresa Maxian (ORCID: https://orcid.org/0000-0002-8009-8479)
- Fabian Coscia (ORCID: https://orcid.org/0000-0002-2244-5081)
- Jens Ulrich
Institutions
- Oslo University Hospital (NO)
- University of Oslo (NO)
- Medical University of Graz (AT)
- Max Delbrück Center (DE)
- Mercy Hospital for Women (AU)
- St George’s University Hospitals NHS Foundation Trust (GB)
- Humboldt-Universität zu Berlin (DE)
- MSB Medical School Berlin (DE)
- King George Hospital (GB)
- Graz University Hospital (AT)
- German Centre for Cardiovascular Research (DE)
- Center For Biomarker Research In Medicine (AT)
- Helios Kliniken (DE)
- Berlin Institute of Health at Charité - Universitätsmedizin Berlin (DE)
- Helios Hospital Berlin-Buch (DE)
- Institute of Molecular Biology and Genetics (UA)
- Freie Universität Berlin (DE)
- Medical University of Vienna (AT)
Publication Details
- Journal
- Hypertension
- Published
- 2024-10-23
- DOI
- https://doi.org/10.1161/hypertensionaha.124.23362
- Citations
- 16
- Primary Topic
- Pregnancy and preeclampsia studies
- Type
- article
- Field-Weighted Citation Impact
- 9.32
Funders
- Deutsche Forschungsgemeinschaft
- Volkswagen Foundation
- Bundesministerium für Bildung und Forschung
- Austrian Science Fund
- Bundesministerium für Wissenschaft, Forschung und Wirtschaft
- Österreichische Forschungsförderungsgesellschaft
- Bundesministerium für Verkehr, Innovation und Technologie
- Steirische Wirtschaftsförderungsgesellschaft
- Karl-Franzens-Universität Graz
- Medizinische Universität Graz
- Bundesministerium für Bildung, Wissenschaft und Forschung
- German Network for Bioinformatics Infrastructure
- Medical Research Council
- National Health and Medical Research Council
- Division of Molecular and Cellular Biosciences