Blood-derived mitochondrial DNA copy number is associated with Alzheimer disease, Alzheimer-related biomarkers and serum metabolites
Our study indicates that mtDNA-CN measured in blood is predictive of AD and is associated with AD biomarkers including plasma NFL particularly in females. Further, we illustrate that decreased mtDNA-CN possibly increases AD risk through dysregulation of mitochondrial lipid metabolism and inflammation.
Authors
- Xiaoling Zhang (ORCID: https://orcid.org/0000-0001-8237-1857)
- Zainab Khurshid (ORCID: https://orcid.org/0000-0002-5857-5443)
- Lindsay A. Farrer (ORCID: https://orcid.org/0000-0001-5533-4225)
- Wei Qiao Qiu (ORCID: https://orcid.org/0000-0002-2082-2410)
- William S. Bush (ORCID: https://orcid.org/0000-0002-9729-6519)
- John J. Farrell (ORCID: https://orcid.org/0000-0001-6502-1572)
- Eden R. Martin (ORCID: https://orcid.org/0000-0002-4035-9152)
- Kathryn L. Lunetta (ORCID: https://orcid.org/0000-0002-9268-810X)
- Congcong Zhu (ORCID: https://orcid.org/0000-0002-1657-8726)
- Tong Tong (ORCID: https://orcid.org/0000-0002-4731-9807)
- Margaret A. Pericak‐Vance
- Gerard Schellenberg
- Li-San Wang
- J. L. Haines
Institutions
- Boston University (US)
- University of Miami (US)
- Case Western Reserve University (US)
- University of Pennsylvania (US)
Publication Details
- Journal
- Alzheimer s Research & Therapy
- Published
- 2024-10-23
- DOI
- https://doi.org/10.1186/s13195-024-01601-w
- Citations
- 21
- Primary Topic
- Mitochondrial Function and Pathology
- Type
- article
- Field-Weighted Citation Impact
- 4.91
Funders
- National Science Foundation
- U.S. Department of Defense
- Alzheimer's Association
- Bristol-Myers Squibb
- Eli Lilly and Company
- Brigham and Women's Hospital
- Biogen
- University of Southern California
- Vanderbilt University
- University of Miami
- University of Pennsylvania
- Alzheimer's Disease Neuroimaging Initiative
- BioClinica
- University of Washington
- Case Western Reserve University
- Wellcome Trust
- EU Joint Programme – Neurodegenerative Disease Research
- GHR Foundation
- Texas Alzheimer's Research and Care Consortium
- Austrian Science Fund
- University of Toronto
- Eisai
- Oesterreichische Nationalbank
- Österreichische Forschungsförderungsgesellschaft
- Karl-Franzens-Universität Graz
- Medizinische Universität Graz
- IXICO
- National Institutes of Health
- Genentech
- Canadian Institutes of Health Research
- Medical Research Council
- National Institute on Aging
- National Heart, Lung, and Blood Institute
- National Human Genome Research Institute
- National Institute of General Medical Sciences
- National Institute of Neurological Disorders and Stroke
- U.S. National Library of Medicine