Four New Tirucallane Triterpenoids from the Leaves of <i>Ailanthus Triphysa</i> with Anti‐Inflammatory Activities
Isolation and determination of three new compounds from the leaves of Ailanthus triphysa (Dennst.) Alston with their anti-inflammatory activity. Ten tirucallane triterpenes (1-10) including four undescribed compounds, ailantriphysas A-D (1-4), were isolated from the leaves of Ailanthus triphysa (Dennst.) Alston. Their structures were elucidated using IR, HR-ESI-MS, 1D- and 2D-NMR spectra. Compound 1 inhibited lipopolysaccharide(LPS)-induced nitric oxide production in RAW 264.7 cells with an IC<sub>50</sub> value of 8.1±μM. Additionally, compound 1 also displayed significant inhibitory effects on the secretion of IL-6 and TNF-α at tested concentrations of 4, 8, and 16 μM.
Authors
- Ngo Anh Bang
- Phan Văn Kiệm (ORCID: https://orcid.org/0000-0003-0756-6990)
- Bùi Hữu Tài (ORCID: https://orcid.org/0000-0002-2034-3786)
- Đỗ Thị Trang (ORCID: https://orcid.org/0000-0002-8378-1038)
- Nguyễn Xuân Cường (ORCID: https://orcid.org/0000-0003-1855-6181)
- Nguyen Duc Duy (ORCID: https://orcid.org/0009-0001-0055-3591)
- Dương Thị Dung (ORCID: https://orcid.org/0000-0001-6948-2333)
- Dương Thị Hải Yến (ORCID: https://orcid.org/0009-0000-8530-4457)
- Nguyêñ Viêt Dũng (ORCID: https://orcid.org/0000-0001-8777-5412)
- Nguyen Thi Thuy (ORCID: https://orcid.org/0000-0003-2342-3797)
- Nguyễn Thị Cúc (ORCID: https://orcid.org/0000-0003-1736-2457)
- Nguyen The Cuong
- Nguyễn Huy Hoàng
- Phạm Hải Yến
- Phan Thị Thanh Hương
Institutions
- Vietnam Academy of Science and Technology (VN)
Publication Details
- Journal
- Chemistry & Biodiversity
- Published
- 2024-10-23
- DOI
- https://doi.org/10.1002/cbdv.202402584
- Primary Topic
- Phytochemical compounds biological activities
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Vietnam Academy of Science and Technology