LC-MS guided discovery of a new type of abyssomicin, glycoabyssomicin A, from a deep-sea derived <i>Streptomyces</i>
Glycoabyssomicin A (<b>1</b>), a new type of abyssomicin containing a sugar unit, was isolated from the deep-sea derived <i>Streptomyces koyangensis</i> SCSIO 5802 guided by LC-MS. The structure of <b>1</b> was elucidated by HR-ESI-MS, 1D-NMR (<sup>1</sup>H,<sup>13</sup>C NMR), 2D-NMR (HSQC, COSY, HMBC, NOESY), and TFA hydrolysis and acetylation reactions. In the antibacterial activities evaluation against a series of gram-positive and gram-negative bacteria, it showed inactive at the concentration of 10 μg per filter paper disc. This finding would broaden the way for discovery of more lead compounds of abyssomicins.
Authors
- Yongxiang Song (ORCID: https://orcid.org/0000-0002-8619-7566)
- Xianglong Zhu (ORCID: https://orcid.org/0000-0003-4700-5688)
- Yan Yan (ORCID: https://orcid.org/0000-0001-6656-7737)
- Ting Chen (ORCID: https://orcid.org/0000-0002-6616-0512)
- Songtao Wang (ORCID: https://orcid.org/0000-0003-1463-6897)
Institutions
- Chinese Academy of Sciences (CN)
- Bay Institute (US)
- Institute of Oceanology (CN)
- South China Sea Institute Of Oceanology (CN)
- Institute of Oceanology (BG)
- University of Chinese Academy of Sciences (CN)
Publication Details
- Journal
- Natural Product Research
- Published
- 2024-10-23
- DOI
- https://doi.org/10.1080/14786419.2024.2417839
- Citations
- 2
- Primary Topic
- Microbial Natural Products and Biosynthesis
- Type
- article
- Field-Weighted Citation Impact
- 0.90
Funders
- National Natural Science Foundation of China
- National Key Research and Development Program of China