Cognitive status and demographics modify the association between subjective cognition and amyloid
Higher SCD was associated with greater cerebral amyloid accumulation, one of the earliest pathological AD changes. SCD appears most useful in detecting early AD-related brain changes prior to objective cognitive impairment, in men, and those with higher quantity and quality of education and highlight the importance of considering these factors.
Authors
- Timothy J. Hohman (ORCID: https://orcid.org/0000-0002-3377-7014)
- Kaj Blennow (ORCID: https://orcid.org/0000-0002-1890-4193)
- Logan C. Dumitrescu (ORCID: https://orcid.org/0000-0002-9782-9944)
- Amalia Jo Peterson (ORCID: https://orcid.org/0000-0002-7015-7957)
- Corey J. Bolton (ORCID: https://orcid.org/0000-0002-1715-5370)
- Omair A. Khan (ORCID: https://orcid.org/0000-0002-9259-9086)
- Angela Lee Jefferson (ORCID: https://orcid.org/0000-0002-8245-0587)
- Sydney Wilhoite
- Henrik Zetterberg (ORCID: https://orcid.org/0000-0003-3930-4354)
- Dandan Liu (ORCID: https://orcid.org/0000-0002-4635-0087)
- Katherine A. Gifford (ORCID: https://orcid.org/0000-0001-6232-9408)
Institutions
- University of Wisconsin–Madison (US)
- Sahlgrenska University Hospital (SE)
- UK Dementia Research Institute (GB)
- National Hospital for Neurology and Neurosurgery (GB)
- University College London (GB)
- University of Gothenburg (SE)
- Vanderbilt University Medical Center (US)
Publication Details
- Journal
- Annals of Clinical and Translational Neurology
- Published
- 2024-10-23
- DOI
- https://doi.org/10.1002/acn3.52209
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Alzheimer's Association
- Alzheimer's Drug Discovery Foundation
- Vanderbilt University
- Familjen Erling-Perssons Stiftelse
- EU Joint Programme – Neurodegenerative Disease Research
- National Institute for Health and Care Research
- University College London
- European Commission
- Vetenskapsrådet
- UK Dementia Research Institute
- HORIZON EUROPE Framework Programme
- National Institute on Aging
- National Center for Advancing Translational Sciences