Enrichment for clinical trials of early AD: Combining genetic risk factors and plasma p‐tau as screening instruments
Participants with unimpaired or mildly impaired cognition were grouped based on cutoffs on genetic risk factors (G: polygenic hazardous score [PHS]) and Alzheimer's pathology (T: baseline plasma phosphorylated tau-181 [p-tau181]). Participants with high PHSs and plasma p-tau181 levels (G+T+) were at risk of faster cognitive decline and AD progression. The combination of PHS and plasma p-tau181 could enhance clinical trial enrichment more effectively than using single biomarkers.
Authors
- Sarah Jane Banks (ORCID: https://orcid.org/0009-0001-6156-0605)
- Anders M. Dale (ORCID: https://orcid.org/0000-0002-6126-2966)
- Iris Broce (ORCID: https://orcid.org/0000-0003-4932-1430)
- Steven D. Edland (ORCID: https://orcid.org/0000-0002-1153-7335)
- Xinran Wang (ORCID: https://orcid.org/0000-0002-5846-4743)
- Xin Wang (ORCID: https://orcid.org/0009-0009-0444-1704)
Institutions
- University of California San Diego (US)
- Human Longevity (United States) (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-10-23
- DOI
- https://doi.org/10.1002/alz.14284
- Citations
- 1
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 0.39
Funders
- U.S. Department of Defense
- U.S. Department of Veterans Affairs
- Alzheimer's Association
- Eli Lilly and Company
- Brigham and Women's Hospital
- Massachusetts General Hospital
- Biogen
- University of Southern California
- Vanderbilt University
- University of Pennsylvania
- Ohio State University
- Northwestern University
- Wake Forest University
- Cleveland Clinic
- Alzheimer's Disease Neuroimaging Initiative
- University of Washington
- University of Pittsburgh
- Georgetown University
- Case Western Reserve University
- Dartmouth College
- Rush University
- Northern California Institute for Research and Education
- Vanderbilt University Medical Center
- University College London
- National Institutes of Health
- University of California, Davis
- University of California, San Diego
- Perelman School of Medicine, University of Pennsylvania
- University of California, San Francisco
- Feinberg School of Medicine
- University of California, Irvine
- School of Medicine, Indiana University
- Houston Methodist Research Institute
- National Institute of Mental Health