The Mesoionic 1,3,4-thiadiazolium Derivative, MI-D, is a Potential Drug for Treating Glioblastoma by Impairing Mitochondrial Functions Linked to Energy Provision in Glioma Cells
The impairment of mitochondrial respiration by MI-D under the condition sustained by oxidative phosphorylation may enhance the cytotoxic effect on A172 glioma cells, although the mechanism of cell death relies on apoptosis.
Authors
- Igor Resendes Barbosa (ORCID: https://orcid.org/0000-0001-8093-3246)
- José Vicente Augusto das Neves Miranda
- Marília Locatelli Corrêa-Ferreira
- Aurea Echevarrı́a (ORCID: https://orcid.org/0000-0002-7330-676X)
- Amanda do Rocio Andrade Pires (ORCID: https://orcid.org/0000-0002-7619-904X)
- Eduardo de Freitas Montin
- Maria Eliane Merlin Rocha (ORCID: https://orcid.org/0000-0001-6790-9196)
- Sílvia Maria Suter Correia Cadena (ORCID: https://orcid.org/0000-0003-4661-8458)
- Gláucia Regina Martinez (ORCID: https://orcid.org/0000-0002-2628-4406)
Institutions
- Universidade Federal Rural do Rio de Janeiro (BR)
- Universidade Federal do Paraná (BR)
Publication Details
- Journal
- Anti-Cancer Agents in Medicinal Chemistry
- Published
- 2024-10-23
- DOI
- https://doi.org/10.2174/0118715206329159241010052746
- Primary Topic
- Genomics, phytochemicals, and oxidative stress
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Conselho Nacional de Desenvolvimento Científico e Tecnológico