Unraveling the Core Components and Critical Targets of Houttuynia cordata Thunb. in Treating Non-small Cell Lung Cancer through Network Pharmacology and Multi-omics Analysis
Through comprehensive network pharmacology and multi-omics analysis, this study predicts that the core components of <i>H. cordata</i> play a role in treating NSCLC by regulating lipid and atherosclerosis, as well as the TNF signaling pathway. Among them, the anti-NSCLC activity of isoramanone is reported for the first time.
Authors
- Ling Xu (ORCID: https://orcid.org/0000-0002-7044-7663)
- Feng Xing (ORCID: https://orcid.org/0000-0001-5209-9143)
- Xinqiang Song (ORCID: https://orcid.org/0000-0001-8119-8597)
- Yang Li (ORCID: https://orcid.org/0000-0001-9055-2332)
- Jiahui Wang (ORCID: https://orcid.org/0000-0002-0867-8612)
- Jinyan Yang
- Yan Zhang (ORCID: https://orcid.org/0000-0002-4835-8541)
Institutions
- Xinyang Normal University (CN)
- Xinyang Central Hospital (CN)
Publication Details
- Journal
- Current Pharmaceutical Design
- Published
- 2024-10-23
- DOI
- https://doi.org/10.2174/0113816128330427241017110325
- Citations
- 2
- Primary Topic
- Nephrotoxicity and Medicinal Plants
- Type
- article
- Field-Weighted Citation Impact
- 0.81