Pathway enrichment in genome‐wide analysis of longitudinal Alzheimer's disease biomarker endophenotypes
A systematic genome-wide analysis with longitudinal AD biomarker endophenotypes was performed. Enriched pathways were identified with functionally derived SNP to gene analysis. Fifty-two pathways were associated with longitudinal trajectory and intercept. Many of the identified pathways are specific steps in larger pathways implicated in AD. The identified pathways may provide therapeutic targets and areas for further study.
Authors
- Shannon L. Risacher (ORCID: https://orcid.org/0000-0002-3304-7943)
- Andrew J. Saykin (ORCID: https://orcid.org/0000-0002-1376-8532)
- Sujuan Gao (ORCID: https://orcid.org/0000-0002-6741-6380)
- Thea Rosewood (ORCID: https://orcid.org/0000-0001-7025-0222)
- Kwangsik Nho (ORCID: https://orcid.org/0000-0002-7624-3872)
- Li Shen (ORCID: https://orcid.org/0000-0002-5443-0503)
- Tatiana M. Foroud
- Shiwei Liu
Institutions
- Indiana University Indianapolis (US)
- Indiana University School of Medicine
- Indiana University – Purdue University Indianapolis (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-10-23
- DOI
- https://doi.org/10.1002/alz.14308
- Citations
- 4
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 1.31
Funders
- U.S. Department of Defense
- Alzheimer's Association
- Indiana Clinical and Translational Sciences Institute
- National Institute on Aging
- National Institute of General Medical Sciences
- U.S. National Library of Medicine
- National Center for Advancing Translational Sciences