<i>Candida guilliermondii</i> fungemia: a 12-year retrospective review of antimicrobial susceptibility patterns at a reference laboratory and tertiary care center

Our study addresses a significant knowledge gap in the clinical management of this non-<i>Candida albicans</i> species. Our retrospective review includes comprehensive AST data for 112 <i>Candida guilliermondii</i> isolates, which is the largest number of isolates reported from the United States to date. Susceptibility data are supplemented by clinical outcomes, where isolates were identified for patients treated at Mayo Clinic. Key findings from our study include the observation that a notable proportion of <i>C. guilliermondii</i> isolates exhibit non-wild-type profiles for various triazoles. Importantly, all isolates remained susceptible to echinocandins, suggesting their efficacy as first-line therapy in the absence of timely susceptibility results. Furthermore, our study highlights the high mortality associated with <i>C. guilliermondii</i> fungemia in immunocompromised patients, emphasizing the urgent need for optimized treatment strategies.