High rate of macrolide resistance and closely genetically related <i>Mycobacterium abscessus</i> complex strains identified among both cystic fibrosis and non-cystic fibrosis patients within two countries
This study highlights the importance of understanding <i>Mycobacterium abscessus</i> transmission because it poses a growing threat to vulnerable populations, especially young cystic fibrosis patients. Investigating how it spreads and which antibiotics work best is crucial for effective treatment. This research used whole genome sequencing to track <i>M. abscessus</i> and found evidence of potential transmission between patients, including across borders. The findings suggest that dominant strains are circulating and some patients may be infected through direct or indirect contact. This knowledge can inform infection control and treatment strategies.
Authors
- Federico Di Marco (ORCID: https://orcid.org/0000-0003-0376-1342)
- Jarmila Hnilicová (ORCID: https://orcid.org/0000-0002-0953-491X)
- Eduard Gondáš (ORCID: https://orcid.org/0000-0001-9014-5630)
- Marek Schwarz (ORCID: https://orcid.org/0000-0002-3300-6260)
- Ivan Solovič
- Andrea Spitaleri (ORCID: https://orcid.org/0000-0003-3012-3557)
- Juraj Mokrý (ORCID: https://orcid.org/0000-0001-7756-5569)
- Věra Dvořáková (ORCID: https://orcid.org/0000-0002-7879-5718)
- Igor Porvazník
- Martina Pinková
- Michaela Hromádková
- Matúš Dohál (ORCID: https://orcid.org/0000-0003-2025-2830)
- Daniela María Cirillo (ORCID: https://orcid.org/0000-0001-6415-1535)
- Michael Rasmussen
- Jana Amlerová (ORCID: https://orcid.org/0000-0002-6056-3740)
Institutions
- Statens Serum Institut (DK)
- Vita-Salute San Raffaele University (IT)
- Charles University (CZ)
- National Center for Tuberculosis and Lung Disease (GE)
- Czech Academy of Sciences, Institute of Microbiology (CZ)
- National Institute of Public Health (CZ)
- Istituti di Ricovero e Cura a Carattere Scientifico (IT)
- Istituto di Ricovero e Cura a Carattere Scientifico San Raffaele (IT)
- Comenius University Bratislava (SK)
- Catholic University of America (US)
Publication Details
- Journal
- Microbiology Spectrum
- Published
- 2024-10-23
- DOI
- https://doi.org/10.1128/spectrum.01056-24
- Citations
- 1
- Primary Topic
- Mycobacterium research and diagnosis
- Type
- article
- Field-Weighted Citation Impact
- 0.39
Funders
- Grantová Agentura České Republiky
- Agentúra na Podporu Výskumu a Vývoja
- Vedecká Grantová Agentúra MŠVVaŠ SR a SAV
- Norwegian Institute of Public Health