Heterogeneity in the Effect of Early Goal-Directed Therapy for Septic Shock: A Secondary Analysis of Two Multicenter International Trials
Treatment response to EGDT varied across patients in two multicenter RCTs with large benefits for some patients while others were harmed. Patient characteristics, including albumin, were most important in identifying HTE.
Authors
- Faraaz Shah (ORCID: https://orcid.org/0000-0002-2847-7738)
- Rinaldo Bellomo (ORCID: https://orcid.org/0000-0002-1650-8939)
- Chung-Chou H. Chang (ORCID: https://orcid.org/0000-0001-8719-2508)
- Sofia Triantafyllou
- David A Harrison (ORCID: https://orcid.org/0000-0002-9002-9098)
- Victor B. Talisa (ORCID: https://orcid.org/0000-0001-5246-0349)
- Gregory F. Cooper (ORCID: https://orcid.org/0000-0002-9276-773X)
- Jason Kennedy (ORCID: https://orcid.org/0000-0001-7604-899X)
- Sachin Yende (ORCID: https://orcid.org/0000-0002-6596-8034)
- Sandra Peake (ORCID: https://orcid.org/0000-0001-6682-7973)
- Florian Mayr (ORCID: https://orcid.org/0000-0002-2298-9011)
- Kimberley M. DeMerle (ORCID: https://orcid.org/0000-0003-1541-8840)
- Christopher Seymour (ORCID: https://orcid.org/0000-0001-8330-8489)
- Paul R. Mouncey (ORCID: https://orcid.org/0000-0002-8510-8517)
- Alisa M. Higgins (ORCID: https://orcid.org/0000-0001-8295-7559)
- Kathy Rowan (ORCID: https://orcid.org/0000-0001-8217-5602)
- Lu Tang (ORCID: https://orcid.org/0000-0002-2682-6578)
- Donald M. Yealy
- Derek C. Angus
Institutions
- The Royal Melbourne Hospital (AU)
- University of Crete (GR)
- The University of Melbourne (AU)
- University of Pittsburgh (US)
- Austin Hospital (AU)
- Australian and New Zealand Intensive Care Society (AU)
- VA Pittsburgh Healthcare System (US)
- Intensive Care National Audit & Research Centre (GB)
- Monash University (AU)
Publication Details
- Journal
- Critical Care Medicine
- Published
- 2024-10-23
- DOI
- https://doi.org/10.1097/ccm.0000000000006463
- Citations
- 16
- Primary Topic
- Sepsis Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 6.19
Funders
- U.S. Department of Veterans Affairs
- University of Pittsburgh
- National Institutes of Health
- Center for Research Computing, University of Pittsburgh
- Medical Research Council
- National Health and Medical Research Council