Heterogeneity in the Effect of Early Goal-Directed Therapy for Septic Shock: A Secondary Analysis of Two Multicenter International Trials

Treatment response to EGDT varied across patients in two multicenter RCTs with large benefits for some patients while others were harmed. Patient characteristics, including albumin, were most important in identifying HTE.

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Publication Details

Journal
Critical Care Medicine
Published
2024-10-23
DOI
https://doi.org/10.1097/ccm.0000000000006463
Citations
16
Primary Topic
Sepsis Diagnosis and Treatment
Type
article
Field-Weighted Citation Impact
6.19

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article

Heterogeneity in the Effect of Early Goal-Directed Therapy for Septic Shock: A Secondary Analysis of Two Multicenter International Trials

Faraaz Shah, Rinaldo Bellomo, Chung-Chou H. Chang, Sofia Triantafyllou et al.
16 citations
Critical Care Medicine
Sepsis Diagnosis and Treatment
6.19
article

Heterogeneity in the Effect of Early Goal-Directed Therapy for Septic Shock: A Secondary Analysis of Two Multicenter International Trials

Faraaz Shah, Rinaldo Bellomo, Chung-Chou H. Chang, Sofia Triantafyllou, David A Harrison, Victor B. Talisa, Gregory F. Cooper, Jason Kennedy, Sachin Yende, Sandra Peake, Florian Mayr, Kimberley M. DeMerle, Christopher Seymour, Paul R. Mouncey, Alisa M. Higgins, Kathy Rowan, Lu Tang, Donald M. Yealy, Derek C. Angus
article en
16 citations

Abstract

Treatment response to EGDT varied across patients in two multicenter RCTs with large benefits for some patients while others were harmed. Patient characteristics, including albumin, were most important in identifying HTE.

Critical Care MedicineVol. 53(1)
The Royal Melbourne Hospital (AU), University of Crete (GR), The University of Melbourne (AU), University of Pittsburgh (US), Austin Hospital (AU), Australian and New Zealand Intensive Care Society (AU), VA Pittsburgh Healthcare System (US), Intensive Care National Audit & Research Centre (GB), Monash University (AU)
U.S. Department of Veterans Affairs, University of Pittsburgh, National Institutes of Health, Center for Research Computing, University of Pittsburgh, Medical Research Council, National Health and Medical Research Council
Good health and well-being
Openalex Percentile: Top 3%
Sepsis Diagnosis and Treatment
6.19
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