Identification and characterization of linear B-cell epitopes on African swine fever virus H171R protein
African swine fever virus (ASFV) poses a severe threat to the global swine industry. This study characterizes linear B-cell epitopes on the crucial ASFV H171R protein, facilitating the development of improved diagnostics and subunit vaccines. Four immunogenic epitopes were identified, offering valuable information for designing sensitive diagnostic assays and potential subunit vaccine candidates. By advancing the understanding of H171R's antigenic landscape, this research contributes to controlling ASFV's devastating impacts, safeguarding the swine industry, and ensuring food security.
Authors
- Aiping Wang
- Gaiping Zhang (ORCID: https://orcid.org/0000-0002-3834-9975)
- Yankai Liu (ORCID: https://orcid.org/0000-0002-6559-2348)
- Jingming Zhou (ORCID: https://orcid.org/0000-0003-2079-1420)
- Hongliang Liu (ORCID: https://orcid.org/0000-0002-7533-6874)
- Cheng Xin (ORCID: https://orcid.org/0009-0009-4586-7242)
- Chao Liang (ORCID: https://orcid.org/0000-0001-6082-1159)
- Yumei Chen (ORCID: https://orcid.org/0000-0002-0241-7577)
- Yanhua Qi (ORCID: https://orcid.org/0000-0002-8796-3226)
- Zhuting Chen
- Xifang Zhu
Institutions
- King University (US)
- Peking University (CN)
- Zhengzhou University (CN)
- Henan Agricultural University (CN)
Publication Details
- Journal
- Microbiology Spectrum
- Published
- 2024-10-23
- DOI
- https://doi.org/10.1128/spectrum.01411-24
- Primary Topic
- Animal Disease Management and Epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 0.00