Enhancing differentiation and functionality of insulin-producing cells derived from iPSCs using esterified collagen hydrogel for cell therapy in diabetes mellitus
Esterified collagen hydrogels demonstrated superior efficacy over 2D and BME in promoting IPC differentiation and maturation, possibly through upregulation of the expression of key secretion pathway genes. Our findings suggest that using collagen hydrogels presents a promising approach to enhance insulin secretion efficiency in differentiating pancreatic β-cells, advancing cell therapy in diabetes cell therapy.
Authors
- Jang Jinah (ORCID: https://orcid.org/0000-0003-3941-3649)
- Ji Eun Moon
- Hye Ryeong Jun
- In Kyong Shim (ORCID: https://orcid.org/0000-0002-1408-9048)
- Song Cheol Kim (ORCID: https://orcid.org/0000-0003-4552-4169)
- Yu Na Lee (ORCID: https://orcid.org/0000-0002-3157-4272)
- Soo‐Jin Jeong (ORCID: https://orcid.org/0000-0001-6529-1767)
- Minh Hien Hoang (ORCID: https://orcid.org/0009-0009-3251-8908)
- Yeonggwon Jo (ORCID: https://orcid.org/0000-0003-4734-0398)
Institutions
- Ulsan College (KR)
- Pohang University of Science and Technology (KR)
- Asan Medical Center (KR)
- University of Ulsan (KR)
Publication Details
- Journal
- Stem Cell Research & Therapy
- Published
- 2024-10-23
- DOI
- https://doi.org/10.1186/s13287-024-03971-2
- Citations
- 12
- Primary Topic
- Pancreatic function and diabetes
- Type
- article
- Field-Weighted Citation Impact
- 6.87
Funders
- National Research Foundation
- Ministry of Trade, Industry and Energy
- Ministry of Health and Welfare
- National Research Foundation of Korea
- Ministry of Education, Science and Technology
- Asan Institute for Life Sciences, Asan Medical Center
- Ministry of Science and ICT, South Korea