Short-Term Effects of Escalating Doses of Cholecalciferol on FGF23 and 24,25(OH)2 Vitamin D Levels: A Preliminary Investigation
25(OH)D and 1,25(OH)D levels significantly increased following 600,000 IU cholecalciferol administration compared to 25,000 I.U. and placebo. Following the massive administration of cholecalciferol, the CYP24A1 enzyme is actively involved in catabolism, thus, avoiding toxic effects.
Authors
- Salvatore Minisola (ORCID: https://orcid.org/0000-0001-6525-0439)
- Mirella Cilli (ORCID: https://orcid.org/0000-0002-7767-6776)
- Cristiana Cipriani (ORCID: https://orcid.org/0000-0002-0141-1202)
- Alfredo Scillitani (ORCID: https://orcid.org/0000-0001-9954-4187)
- Carla Ferrara (ORCID: https://orcid.org/0000-0002-8628-829X)
- Viviana De Martino (ORCID: https://orcid.org/0000-0002-7034-7718)
- Luciano Colangelo (ORCID: https://orcid.org/0000-0002-5835-9310)
- Roberta Pilotto
- Ravinder J. Singh (ORCID: https://orcid.org/0000-0003-4538-6544)
- Jessica Pepe (ORCID: https://orcid.org/0000-0003-1566-6553)
Institutions
- Mayo Clinic (US)
- Istituto Superiore di Sanità (IT)
- Casa Sollievo della Sofferenza (IT)
- WinnMed (US)
- Istituti di Ricovero e Cura a Carattere Scientifico (IT)
- Sapienza University of Rome (IT)
Publication Details
- Journal
- Nutrients
- Published
- 2024-10-23
- DOI
- https://doi.org/10.3390/nu16213600
- Citations
- 3
- Primary Topic
- Vitamin D Research Studies
- Type
- article
- Field-Weighted Citation Impact
- 1.27