Inhibiting mtDNA transcript translation alters Alzheimer's disease‐associated biology
In AD, mitochondrial dysfunction could represent a disease cause or consequence. We inhibited mitochondrial translation in human neuronal cells and neurons. Mitochondrial and nuclear gene expression shifted in adaptive-consistent patterns. APP, Aβ, APOE, tau, and α-synuclein biology changed in AD-consistent patterns. Mitochondrial stress creates an environment that promotes AD pathology.
Authors
- Artyom Kopp (ORCID: https://orcid.org/0000-0001-5224-0741)
- Xiaowan Wang (ORCID: https://orcid.org/0000-0001-9152-8908)
- Anysja Roberts (ORCID: https://orcid.org/0009-0009-6247-0175)
- Nicholas J. Ernst (ORCID: https://orcid.org/0000-0002-6401-3041)
- Alexander P. Gabrielli (ORCID: https://orcid.org/0000-0001-8019-5407)
- Heather Wilkins (ORCID: https://orcid.org/0000-0003-4563-4544)
- Colton R Lysaker
- Russell Howard Swerdlow (ORCID: https://orcid.org/0000-0003-2948-7230)
- Lesya V. Novikova (ORCID: https://orcid.org/0000-0002-0087-431X)
- Amol Ranjan (ORCID: https://orcid.org/0000-0002-4198-1007)
- Clayton O. Mansel (ORCID: https://orcid.org/0000-0002-0135-7576)
- Dhanushki Abeykoon
- Lijuan Qiao (ORCID: https://orcid.org/0009-0005-1512-481X)
- Ian W. Wiedling
Institutions
- University of Kansas (US)
- University of Kansas Medical Center (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-10-23
- DOI
- https://doi.org/10.1002/alz.14275
- Citations
- 5
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 1.63
Funders
- Thompson Foundation
- Royal Historical Society
- National Institutes of Health
- National Institute on Aging