Interleukin-38 ameliorates myocardial Ischemia-Reperfusion injury via inhibition of NLRP3 inflammasome activation in fibroblasts through the IL-1R8/SYK axis
IL-38 acts as a potent negative regulator of inflammasome activation after MIRI. It achieves this regulatory effect within cardiac fibroblasts by inhibiting SYK phosphorylation, a process mediated by IL-1R8.
Authors
- Rui Shen (ORCID: https://orcid.org/0000-0002-5704-4632)
- Kunwu Yu (ORCID: https://orcid.org/0000-0003-2414-5960)
- Jiangmei Zhang
- Ruirui Zhu (ORCID: https://orcid.org/0000-0002-6472-8450)
- Yan Ding (ORCID: https://orcid.org/0000-0002-5034-1212)
- Zhiyang Li (ORCID: https://orcid.org/0000-0002-8928-7671)
- Chen Dong (ORCID: https://orcid.org/0000-0002-0084-9130)
- Chengliang Pan (ORCID: https://orcid.org/0000-0002-0223-7461)
- Qiutang Zeng (ORCID: https://orcid.org/0000-0002-1886-0725)
Institutions
- Wuhan Union Hospital (CN)
- Union Hospital (CN)
Publication Details
- Journal
- International Immunopharmacology
- Published
- 2024-10-23
- DOI
- https://doi.org/10.1016/j.intimp.2024.113428
- Citations
- 6
- Primary Topic
- Inflammasome and immune disorders
- Type
- article
- Field-Weighted Citation Impact
- 1.40
Funders
- National Natural Science Foundation of China