A collaborative effort across Africa to investigate risk factors and outcomes of premature acute coronary syndrome: Protocol for the EAS Lipid Registry of Africa (LIPRA)

Data on acute coronary syndrome (ACS) is lacking in Africa where cases of premature ACS seem to be on the rise. Africa would benefit from an epidemiological assessment of premature ACS to determine its risk factors and management in this demographic to inform guidelines and practice. The European Atherosclerosis Society recognised this urgency and formed a growing network across 11 African countries to create the Lipid Registry of Africa (EAS-LIPRA). This article is based on the EAS-LIPRA protocol and presents the aims, concept and methodological considerations, and the operations and collaborative governance structure of this project. EAS-LIPRA aims to report risk factors and outcomes of premature ACS in Africa to further understand its prevalence and management via collating and pooling multinational prospective data on premature ACS across multiple sites in Africa into a standardised registry. Data will be stratified into subgroups based on country-level income as defined by the World Bank, and within country residence of urban versus rural areas. Valid statistical procedures will be employed to compare and observe trends in the pooled data based on demographics, clinical and laboratory variables, and disparities in its management. Being the first multinational lipid registry in Africa, it is envisaged that the network will expand to other African countries and sites yet to participate, facilitate other epidemiological studies in preventive cardiology, and set a precedent for other developing countries and regions.

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Publication Details

Journal
Atherosclerosis Plus
Published
2024-10-24
DOI
https://doi.org/10.1016/j.athplu.2024.10.002
Citations
3
Primary Topic
Lipoproteins and Cardiovascular Health
Type
article
Field-Weighted Citation Impact
1.72

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article

A collaborative effort across Africa to investigate risk factors and outcomes of premature acute coronary syndrome: Protocol for the EAS Lipid Registry of Africa (LIPRA)

Ashraf Reda, Ahmed Bendary, Chala Fekadu, Lilian Kagure Mbau et al.
3 citations
Atherosclerosis Plus
Lipoproteins and Cardiovascular Health
1.72
article

A collaborative effort across Africa to investigate risk factors and outcomes of premature acute coronary syndrome: Protocol for the EAS Lipid Registry of Africa (LIPRA)

Ashraf Reda, Ahmed Bendary, Chala Fekadu, Lilian Kagure Mbau, Anastase Dzudié, Atef Elbahry, Mohammed Mujahed, Mahmoud Umar Sani, Okechukwu S. Ogah, Habib Gamra, Lambert Appiah, Mutaz Al-Khnifsawi, Bernard Samia, Alberto Zambon, Julius Chacha Mwita, Ahmed Suliman, Alexander R.M. Lyons, Albertino Antonio Moura Damasceno, Tigist Seleshi, David Marais, Elsayed Farag, Rosemary P. Minja, Alexandros D. Tselepis
article en
3 citations

Abstract

Data on acute coronary syndrome (ACS) is lacking in Africa where cases of premature ACS seem to be on the rise. Africa would benefit from an epidemiological assessment of premature ACS to determine its risk factors and management in this demographic to inform guidelines and practice. The European Atherosclerosis Society recognised this urgency and formed a growing network across 11 African countries to create the Lipid Registry of Africa (EAS-LIPRA). This article is based on the EAS-LIPRA protocol and presents the aims, concept and methodological considerations, and the operations and collaborative governance structure of this project. EAS-LIPRA aims to report risk factors and outcomes of premature ACS in Africa to further understand its prevalence and management via collating and pooling multinational prospective data on premature ACS across multiple sites in Africa into a standardised registry. Data will be stratified into subgroups based on country-level income as defined by the World Bank, and within country residence of urban versus rural areas. Valid statistical procedures will be employed to compare and observe trends in the pooled data based on demographics, clinical and laboratory variables, and disparities in its management. Being the first multinational lipid registry in Africa, it is envisaged that the network will expand to other African countries and sites yet to participate, facilitate other epidemiological studies in preventive cardiology, and set a precedent for other developing countries and regions.

Atherosclerosis PlusVol. 58
Western Cape Department of Health (ZA), Université de Yaoundé I (CM), University of Padua (IT), University of Khartoum (SD), University of Botswana (BW), University of Cape Town (ZA), University of Douala (CM), University of Monastir (TN), Eduardo Mondlane University (MZ), Zagazig University (EG), University of Ioannina (GR), University of Washington (US), Benha University (EG), Nairobi Hospital (KE), University College Hospital, Ibadan (NG), Kwame Nkrumah University of Science and Technology (GH), University of Al-Qadisiyah (IQ), Maputo Central Hospital (MZ), Sudan Medical Specialization Board (SD), Muhimbili National Hospital (TZ), Child Welfare Society of Kenya (KE), European Atherosclerosis Society (SE), University of Kerbala (IQ), Centers for Disease Control and Prevention (KE), Aminu Kano Teaching Hospital (NG), Amsterdam University Medical Centers (NL), Institute for Atherosclerosis Research (RU), Menoufia University Hospitals (EG), University of Warith Al-Anbiyaa, Addis Ababa University (ET), Menoufia University (EG), Port Said University (EG), University of Amsterdam (NL), Bayero University Kano (NG)
European Atherosclerosis Society
Good health and well-being
Openalex Percentile: Top 15%
Lipoproteins and Cardiovascular Health
1.72
DOIOpen Access PDFOpenAlex
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