Cisplatin-resistance and aggressiveness are enhanced by a highly stable endothelin-converting enzyme-1c in lung cancer cells
Our findings suggest an important role of ECE-1c in lung cancer. ECE-1c is key in a non-canonical ET-1-independent mechanism which triggers a CSC-like phenotype, leading to enhanced lung cancer aggressiveness. Underlying this mechanism, ECE-1c is stabilized upon phosphorylation by CK2, which is upregulated in many cancers. Thus, phospho-ECE-1c may be considered as a novel prognostic biomarker of recurrence, as well as the CK2 inhibitor silmitasertib as a potential therapy for lung cancer patients.
Authors
- Rodrigo López‐Muñoz (ORCID: https://orcid.org/0000-0003-1825-8563)
- Karla Villalobos-Nova (ORCID: https://orcid.org/0000-0002-5559-9546)
- Julio C. Tapia (ORCID: https://orcid.org/0000-0003-1678-2708)
- Eduardo Silva-Pavez (ORCID: https://orcid.org/0000-0002-9650-7521)
- Francisco Aguayo (ORCID: https://orcid.org/0000-0002-9619-7535)
- Lilian Jara (ORCID: https://orcid.org/0000-0001-5068-7259)
- Verónica A. Burzio (ORCID: https://orcid.org/0000-0002-6491-4640)
- Ignacio Niechi (ORCID: https://orcid.org/0000-0003-1857-8698)
- Belén Gaete‐Ramírez (ORCID: https://orcid.org/0000-0002-4620-8419)
- Manuel Varas‐Godoy (ORCID: https://orcid.org/0000-0001-5857-4793)
- David A. Brown‐Brown
- María de los Ángeles Toro (ORCID: https://orcid.org/0009-0001-5993-2756)
- Manuel A. González
- Cristopher Almarza
Institutions
- Universidad Andrés Bello (CL)
- Austral University of Chile (CL)
- University of Tarapacá (CL)
- San Sebastián University (CL)
- University of Chile (CL)
Publication Details
- Journal
- Biological Research
- Published
- 2024-10-24
- DOI
- https://doi.org/10.1186/s40659-024-00551-9
- Citations
- 3
- Primary Topic
- Cancer, Hypoxia, and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 0.86
Funders
- Agenția Națională pentru Cercetare și Dezvoltare
- Agencia Nacional de Investigación y Desarrollo
- CHIST-ERA