Autophagy deficiency exacerbated hypoxia-reoxygenation induced inflammation and cell death via a mitochondrial DNA/STING/IRF3 pathway
Autophagy deficiency in the cardiomyocyte setting results in detrimental effects during I/R injury in mice or H/R injury in cells, mediated in part via mtDNA/IRF3/STING pathway. As such, modulation of this pathway may yield novel and promising therapeutics to treat or prevent I/R injury.
Authors
- Boris Hinz (ORCID: https://orcid.org/0000-0002-0526-393X)
- Eddie Tam (ORCID: https://orcid.org/0009-0002-8480-7145)
- Aimin Xu (ORCID: https://orcid.org/0000-0002-0668-033X)
- Gary Sweeney (ORCID: https://orcid.org/0000-0002-1946-1347)
- Nina Noskovičová
- Erfei Song (ORCID: https://orcid.org/0000-0002-2492-5820)
Institutions
- St. Michael's Hospital (CA)
- University of Toronto (CA)
- York University (CA)
- Pharmaceutical Biotechnology (Czechia) (CZ)
- University of Hong Kong (HK)
Publication Details
- Journal
- Life Sciences
- Published
- 2024-10-24
- DOI
- https://doi.org/10.1016/j.lfs.2024.123173
- Citations
- 8
- Primary Topic
- Autophagy in Disease and Therapy
- Type
- article
- Field-Weighted Citation Impact
- 3.09
Funders
- Heart and Stroke Foundation of Canada