ESTRO-EANO guideline on target delineation and radiotherapy for IDH-mutant WHO CNS grade 2 and 3 diffuse glioma
The GTV should include any residual tumour volume after surgery, as well as the resection cavity. Enhancing lesions on T1 imaging should be included if they are indicative of residual tumour. In grade 2 tumours, T2/FLAIR abnormalities should be included in the GTV. In grade 3 tumours, T2/FLAIR abnormalities should also be included, except areas that are considered to be oedema which should be omitted from the GTV. A GTV to CTV expansion of 10 mm is recommended in grade 2 tumours and 15 mm in grade 3 tumours. A treatment dose of 50.4 Gy in 28 fractions is recommended in grade 2 tumours and 59.4 Gy in 33 fractions in grade 3 tumours. Radiation techniques with IMRT are the preferred approach.
Authors
- Martin J. van den Bent (ORCID: https://orcid.org/0000-0001-5710-5127)
- Vera C. Keil (ORCID: https://orcid.org/0000-0001-8699-3506)
- Anca-Ligia Grosu (ORCID: https://orcid.org/0000-0003-2255-2255)
- Norbert Galldiks (ORCID: https://orcid.org/0000-0002-2485-1796)
- Sara Erridge (ORCID: https://orcid.org/0000-0003-3411-2505)
- Umberto Ricardi (ORCID: https://orcid.org/0000-0003-4406-7621)
- Damien C. Weber (ORCID: https://orcid.org/0000-0003-1166-8236)
- Maximilian Niyazi (ORCID: https://orcid.org/0000-0002-7711-9486)
- Jaap Jaspers (ORCID: https://orcid.org/0000-0002-1904-4914)
- Brigitta G. Baumert (ORCID: https://orcid.org/0000-0001-8871-4654)
- Ewa Iżycka‐Świeszewska (ORCID: https://orcid.org/0000-0001-7550-1326)
- Giuseppe Caracciolo Minniti (ORCID: https://orcid.org/0000-0003-1239-1603)
- F. Dhermain
- Roberta Rudà (ORCID: https://orcid.org/0000-0001-9134-1537)
- Beate Timmermann
Institutions
- Radboud University Nijmegen (NL)
- University Medical Center Freiburg (DE)
- Institut Gustave Roussy (FR)
- Paul Scherrer Institute (CH)
- Edinburgh Cancer Research (GB)
- Radboud University Medical Center (NL)
- Düsseldorf University Hospital (DE)
- Integrated Oncology (United States) (US)
- Essen University Hospital (DE)
- University Children's Hospital Tübingen (DE)
- Bernstein Center for Computational Neuroscience Tübingen (DE)
- Kantonsspital Graubünden (CH)
- Erasmus MC Cancer Institute (NL)
- Amsterdam University Medical Centers (NL)
- University Hospital Cologne (DE)
- West German Heart and Vascular Center Essen (DE)
- Heinrich Heine University Düsseldorf (DE)
- University of Turin (IT)
- Gdańsk Medical University (PL)
- University of Tübingen (DE)
- Sapienza University of Rome (IT)
Publication Details
- Journal
- Radiotherapy and Oncology
- Published
- 2024-10-24
- DOI
- https://doi.org/10.1016/j.radonc.2024.110594
- Citations
- 18
- Primary Topic
- Glioma Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 7.45