Impacts of Pta-AckA pathway on CPS biosynthesis and type 3 fimbriae expression in Klebsiella pneumoniae
Our findings highlight the critical role of the Pta-AckA pathway in K. pneumoniae pathogenesis. This pathway regulates AcP levels, global protein acetylation, CPS production, serum resistance, and type 3 fimbriae expression, ultimately impacting virulence. The information provides insights into potential therapeutic targets for combating K. pneumoniae infection.
Authors
- Chen‐Yu Wang (ORCID: https://orcid.org/0000-0002-3912-5113)
- Chien-Chen Wu
- Ching‐Ting Lin (ORCID: https://orcid.org/0000-0002-6925-9999)
- Tien-Huang Lin
Institutions
- National Yang Ming Chiao Tung University (TW)
- China Medical University (TW)
- Tzu Chi University (TW)
- Tzu Chi Foundation (TW)
- Taipei Tzu Chi Hospital (TW)
- China Medical University Hospital (TW)
- Buddhist Tzu Chi Medical Foundation (US)
Publication Details
- Journal
- Journal of Microbiology Immunology and Infection
- Published
- 2024-10-24
- DOI
- https://doi.org/10.1016/j.jmii.2024.10.002
- Citations
- 2
- Primary Topic
- Antibiotic Resistance in Bacteria
- Type
- article
- Field-Weighted Citation Impact
- 0.34
Funders
- Ministry of Science and Technology, Taiwan
- Buddhist Tzu Chi Medical Foundation
- China Medical University, Taiwan