Carbenoxolone upregulates TRAIL\TRAILR2 expression and enhances the anti-neoplastic effect of doxorubicin in experimentally induced hepatocellular carcinoma in rats
The current study proposes that CBX is a promising anti-tumor compound, which can work effectively under prophylactic and therapeutic modes. Interestingly, CBX enhanced the anti-tumor effect of DOX. CBX exerted these effects via, in part, stimulating TRAIL-induced apoptosis along with attenuating fibrosis.
Authors
- Nada H. Eisa (ORCID: https://orcid.org/0000-0001-8630-0693)
- Mohamed El‐Sherbiny (ORCID: https://orcid.org/0000-0002-0814-1743)
- Amal M. El Gayar
- Mohamed El‐Mesery
- Iman M El-Zehery
Institutions
- Mansoura University (EG)
- University of Konstanz (DE)
Publication Details
- Journal
- Biochemical and Biophysical Research Communications
- Published
- 2024-10-24
- DOI
- https://doi.org/10.1016/j.bbrc.2024.150876
- Citations
- 2
- Primary Topic
- Cell death mechanisms and regulation
- Type
- article
- Field-Weighted Citation Impact
- 0.47