An Expression Quantitative Trait Locus of Fc Gamma Receptor Genes Is Associated With Antimalarial IgG Responses and Infection Levels in Burkinabe Families
Our findings suggest that the intergenic variant rs1771575 serves as an independent marker for IgG levels and blood infection in children. This highlights the interplay between regulatory variants and coding mutations in FCGR, which may influence immune function and antibody production. These results underscore the potential for personalized strategies to monitor humoral responses in malaria-endemic regions.
Authors
- Pascale Paul (ORCID: https://orcid.org/0000-0002-6734-4479)
- Frédéric Gallardo (ORCID: https://orcid.org/0000-0002-8565-9730)
- Pascal Rihet (ORCID: https://orcid.org/0000-0002-9459-3905)
- Serge Aimé Sawadogo
- Christophe Picard (ORCID: https://orcid.org/0000-0001-9118-5239)
- Mathieu Adjemout (ORCID: https://orcid.org/0000-0002-3500-1121)
- J Crétin
- Magali Torres (ORCID: https://orcid.org/0000-0002-7760-3809)
- Christelle Dieppois
Institutions
- Université Joseph Ki-Zerbo (BF)
- Inserm (FR)
- Aix-Marseille Université (FR)
- Centre National pour la Recherche Scientifique et Technique (CNRST) (MA)
- Theories and Approaches of Genomic Complexity (FR)
- Établissement Français du Sang (FR)
Publication Details
- Journal
- The Journal of Infectious Diseases
- Published
- 2024-10-25
- DOI
- https://doi.org/10.1093/infdis/jiae528
- Primary Topic
- Monoclonal and Polyclonal Antibodies Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Aix-Marseille Université
- Institut National de la Santé et de la Recherche Médicale