Frontiers of myopia research in the 21st century: A bibliometric analysis of the top 100 most influential articles in the field

Myopia is the most common refractive error worldwide, contributing not only to visual impairment but also serving as a potential risk factor for various severe ocular diseases. Its impact on patients' quality of life and health is significant and imposes substantial socioeconomic burdens. In this study, we analyzed the top 100 most cited articles related to myopia published in the Web of Science Core Collection database from January 2000 to February 2024. Using data visualization tools CiteSpace, VOSviewer, and Scimago Graphica, we identified the most influential research papers and academic journals in the field of myopia. The top 100 most influential articles were published in 25 renowned journals across 30 countries, with Investigative Ophthalmology & Visual Science being the most prolific. Ophthalmology had the highest total citation frequency, while The Lancet had the highest average citation frequency. The United States and the National University of Singapore were the top countries and institutions with the most published papers. The 3 major research directions are Ophthalmology, Medicine, General & Internal, and Genetics & Heredity. The top 5 co-occurring keywords were refractive error, risk factors, prevalence, eye growth, and form-deprivation myopia. Cluster analysis results highlighted focal points such as retinal detachment, high myopia, and contrast sensitivity, indicating potential future research trends. Prospective research directions include investigating the pathogenesis of myopia, updating diagnostic technologies, and identifying risk genes for myopia and its complications.