Stress resilience is an active and multifactorial process manifested by structural, functional, and molecular changes in synapses
Stress resilience is the ability of neuronal networks to maintain their function despite the stress exposure. Using a mouse model we investigate stress resilience phenomenon. To assess the resilient and anhedonic behavioral phenotypes developed after the induction of chronic unpredictable stress, we quantitatively characterized the structural and functional plasticity of excitatory synapses in the hippocampus using a combination of proteomic, electrophysiological, and imaging methods. Our results indicate that stress resilience is an active and multifactorial process manifested by structural, functional, and molecular changes in synapses. We reveal that chronic stress influences palmitoylation of synaptic proteins, whose profiles differ between resilient and anhedonic animals. The changes in palmitoylation are predominantly related with the glutamate receptor signaling thus affects synaptic transmission and associated structures of dendritic spines. We show that stress resilience is associated with structural compensatory plasticity of the postsynaptic parts of synapses in CA1 subregion of the hippocampus.
Authors
- Monika Zaręba-Kozioł (ORCID: https://orcid.org/0000-0003-3544-6259)
- Remigiusz Worch (ORCID: https://orcid.org/0000-0002-3222-4821)
- Evgeni G. Ponimaskin (ORCID: https://orcid.org/0000-0002-4570-5130)
- Kasia Radwańska (ORCID: https://orcid.org/0000-0001-7445-6180)
- Matylda Roszkowska (ORCID: https://orcid.org/0000-0001-9280-8063)
- Adam Krzystyniak (ORCID: https://orcid.org/0000-0003-3306-8047)
- Monika Bijata (ORCID: https://orcid.org/0000-0003-0589-4771)
- Bartłomiej Pochwat (ORCID: https://orcid.org/0000-0002-3785-6721)
- Ewa Bączyńska (ORCID: https://orcid.org/0000-0003-0858-4816)
- Marta Magnowska (ORCID: https://orcid.org/0000-0002-5424-6837)
- Krzysztof H. Olszyński (ORCID: https://orcid.org/0000-0003-2114-4487)
- Adam S. Hogendorf (ORCID: https://orcid.org/0000-0003-3311-3266)
- Agnieszka D. Wardak (ORCID: https://orcid.org/0000-0003-1799-8949)
- Krystian Bijata (ORCID: https://orcid.org/0000-0002-7535-0457)
- Josephine Labus (ORCID: https://orcid.org/0000-0002-5064-6382)
- Jakub Włodarczyk (ORCID: https://orcid.org/0000-0001-8343-2340)
- Bernadeta Szewczyk (ORCID: https://orcid.org/0000-0002-6863-7951)
- Błażej Ruszczycki (ORCID: https://orcid.org/0000-0002-0262-1463)
- Piotr Szymczak (ORCID: https://orcid.org/0000-0001-8940-7891)
- Agata Pytyś (ORCID: https://orcid.org/0000-0002-2494-7034)
- Izabela Figiel (ORCID: https://orcid.org/0000-0001-5028-0168)
- Tomasz Wójtowicz (ORCID: https://orcid.org/0000-0003-1128-4363)
- Robert K. Filipkowski (ORCID: https://orcid.org/0000-0002-9911-9751)
- Joanna Dzwonek (ORCID: https://orcid.org/0000-0002-3834-2175)
- Julia Masternak
- P Jahołkowski
Institutions
- Oslo University Hospital (NO)
- University of Oslo (NO)
- Medizinische Hochschule Hannover (DE)
- National Institute of Oncology (HU)
- Maj Institute of Pharmacology (PL)
- The Maria Sklodowska-Curie National Research Institute of Oncology (PL)
- Mossakowski Medical Research Institute, Polish Academy of Sciences (PL)
- University of Warsaw (PL)
- AGH University of Krakow (PL)
- Polish Academy of Sciences (PL)
Publication Details
- Journal
- Neurobiology of Stress
- Published
- 2024-10-21
- DOI
- https://doi.org/10.1016/j.ynstr.2024.100683
- Citations
- 6
- Primary Topic
- Adipose Tissue and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 1.96
Funders
- Deutsche Forschungsgemeinschaft
- Narodowe Centrum Nauki
- Ministry of Education and Science
- Instytut Biologii Doswiadczalnej im. M. Nenckiego PAN