PAD inhibition downregulates the cellular fibrotic behavior of senescent myofibroblasts derived from dilated cardiomyopathy
This study revealed that elevated PAD expression facilitates cellular processes mainly senescence, migration, and invasion. PAD inhibition resulted in the downregulation of these cellular functions, thereby reducing the fibrotic behavior of DCM myofibroblasts.
Authors
- Justyna Fert‐Bober (ORCID: https://orcid.org/0000-0002-2824-5056)
- Alia Sadiq (ORCID: https://orcid.org/0000-0003-3080-7991)
Institutions
- Cedars-Sinai Medical Center (US)
- Cedars-Sinai Smidt Heart Institute (US)
Publication Details
- Journal
- Biomedicine & Pharmacotherapy
- Published
- 2024-10-21
- DOI
- https://doi.org/10.1016/j.biopha.2024.117579
- Citations
- 3
- Primary Topic
- Cardiac Fibrosis and Remodeling
- Type
- article
- Field-Weighted Citation Impact
- 1.21