Effect of Tranexamic acid local injection in anterior cruciate ligament reconstruction on blood loss

Hemarthrosis after anterior cruciate ligament (ACL) reconstruction procedures can delay rehabilitation and have toxic effects on the cartilage and synovium. the use of TXA in arthroscopic procedures has become a topic of novel study, as use may decrease the frequency of postoperative hemarthrosisMethods: Our study was conducted on fIfty patients (48 males and 2 females), The age varied between 16 and 50 years with a mean age of (22-35). The patients were randomized into two groups, Patients in the TXA group (n =25) underwent ACLR and a 10-mL intraarticular injection of TXA after the procedure & Patients in the control group (n = 25) only ACLR without TXA injections. Results: the decrease in drainage volume was less in the TXA group than in the Control group. Also, the amount of drainage was significantly reduced in TXA patients who underwent different meniscal procedures. decrease in HB level was less in TXA group than in the Control group. patients receiving intra-articular injections of TXA showed a significant decrease in mean hemarthrosis grade within the first 2 weeks (TXA group, 0.24±0.47, and control group, 1.52±0.49. Conclusion: intra-articular injection of TXA could be considered an effective, efficient, and reproducible method for reducing blood loss and hemarthrosis, with the potential to reduce patient discomfort after arthroscopic ACL reconstruction (ACLR).