Clinical and biochemical investigation in subclinical hypophosphatemia in relation to indigestion in Egyptian buffaloes

Hypophosphatemia is recognized as a major and economic metabolic disorder of highly incidence in buffaloes in Egypt. This study spots high lights on some clinical and biochemical changes in buffaloes with sub clinical hypophosphatemia (SCH). Clinical examination of 35 affected and another 10 apparently healthy buffaloes was carried out. The results of clinical examination revealed that SCH buffaloes were suffered from rectal temperature of 38.9oc, slightly increased Heart rate, decrease body weight, anorexia, stiffness in gait, pale mucous membrane of vulva and conjunctiva, decreased milk production, ruminal hypo motile and constipation and biochemical analysis revealed a highly significant decrease in the mean values of total protein (TP) and a significant decrease in albumin of buffaloes with hypophosphatemia compared with control group, and A highly significant increase in the mean values of a aspartate transaminase (AST) and Alanine transaminase (ALT) of buffalo with hypophosphatemia compared with control group in addition to, a highly significant decrease in the mean values of glucose 6 phosphate (G-6-P), calcium (Ca2+), phosphorus (P-), potassium (K+) and chloride (CL-) of buffalo with hypophosphatemia compared with control group.This conclude that phosphorous deficiency leading to defect in G-6-P and cellular energy metabolism (ATP) due to increase in liver enzymes as a result to liver disorders, this leading to ruminal hypo motile and ruminal stasis and economic losses due to weight loss and decline in milk production.