Alleviating reproductive dysfunction of lead acetate in male rat: The role of curcumin and metformin

To evaluate the ameliorative consequences of curcumin and metformin or their combination on lead reproductive toxic effect, 30 male Wister rats divided in to five groups as follow: Group 1 negative control. Group 2 lead acetate (50mg\kg B.W) orally for 6 weeks. Group 3 treated with same lead dose and curcumin (400mg\kg B.W) orally for 6 weeks. Group 4 treated with same lead dose and metformin (30mg\kg B.W) orally for 6 weeks and Group 5 treated with same lead dose and combination of curcumin with metformin (400mg\kg and 30mg\kg B.W) orally for 6 weeks respectively. With completion of study duration, all animal sacrificed, blood, serum sample obtained for hormonal evaluation along testes tissue for histopathological study. Result shows an improvement of hormonal levels and alleviation of structural changes induced by lead with curcumin and\ or metformin thus protective reproductive function achieved, also noted that curcumin produce better effect than metformin.