An <i>Acinetobacter baumannii</i> nasal carriage isolate recovered from an asymptomatic patient in Vietnam is extensively antibiotic resistant and produces a rare K71 type capsule
The majority of <i>Acinetobacter baumannii</i> genomes sequenced and analyzed to develop an understanding of extensively drug-resistant (XDR) isolates belong to the globally disseminated CC2 clonal complex. While XDR isolates belonging to rarer lineages are often unexplored, detailed analyses could provide novel insights into the spread of resistance, as well as cell surface features such as the CPS that determine the specificity of non-antibiotic therapeutics required to treat XDR infections that resist antimicrobial chemotherapy. Here, we describe the properties of an XDR asymptomatic nasal carriage isolate recovered in Vietnam that belongs to ST142, a rarely encountered sequence type. We report the resistance profile and correlate this with detected resistance determinants. We also solve the structure of the CPS and reveal its relationship with CPS produced by other <i>A. baumannii</i> isolates.
Authors
- Andrey S. Dmitrenok (ORCID: https://orcid.org/0000-0003-3736-0459)
- Johanna J. Kenyon (ORCID: https://orcid.org/0000-0002-1487-6105)
- Christopher J. Harmer (ORCID: https://orcid.org/0000-0003-1486-454X)
- Andrei V. Perepelov (ORCID: https://orcid.org/0000-0001-9919-9803)
- Anastasiya V. Popova (ORCID: https://orcid.org/0000-0003-0065-6459)
- Anastasiya A. Kasimova (ORCID: https://orcid.org/0000-0002-6685-4098)
- Ruth M. Hall (ORCID: https://orcid.org/0000-0003-2062-3312)
- Yuriy A. Knirel
- Alexander O. Chizhov (ORCID: https://orcid.org/0000-0002-4219-8890)
- Anna M. Shpirt
- Mikhail M. Shneider
- Alexander S. Shashkov
Institutions
- Griffith University (AU)
- The University of Sydney (AU)
- N.D. Zelinsky Institute of Organic Chemistry (RU)
- Institute of Bioorganic Chemistry (RU)
- State Research Center for Applied Microbiology and Biotechnology (RU)
Publication Details
- Journal
- Microbiology Spectrum
- Published
- 2024-10-22
- DOI
- https://doi.org/10.1128/spectrum.01838-24
- Citations
- 3
- Primary Topic
- Antibiotic Resistance in Bacteria
- Type
- article
- Field-Weighted Citation Impact
- 0.51
Funders
- Department of Health and Aged Care, Australian Government
- Russian Science Foundation
- Department of Education and Training
- Medical Research Council
- National Health and Medical Research Council