Photocatalyst-Free Transformation of C(sp<sup>3</sup>)–H Bonds to Oxime Ethers via Photoinduced Hydrogen Atom Transfer
Herein, a direct transformation of aliphatic C-H bonds to oxime ethers has been developed via light-promoted hydrogen atom transfer (HAT) in the absence of a photocatalyst. Singlet oxygen and chlorine radical are complementary C(sp<sup>3</sup>)-H bond cleaving agents in this reaction, enabling the extraction of hydrogen atoms from a diverse range of compounds, like cycloalkanes, ethers, amines, amides, and cyclic sulfides. This method excels in transforming common aliphatic C-H bonds into valuable oxime ethers featuring abundant chemical feedstocks, good functional group tolerance, and catalyst free conditions.
Authors
- Xiaole Han (ORCID: https://orcid.org/0000-0002-7515-6291)
- Wei Yi (ORCID: https://orcid.org/0000-0001-7936-9326)
- Lijing Li (ORCID: https://orcid.org/0000-0001-5195-6270)
- Xiao‐Qiang Hu (ORCID: https://orcid.org/0000-0001-9094-2357)
- Xuehong Min
- Yulian Zhao
Institutions
- Minzu University of China (CN)
- Wuhan Business University (CN)
- Horse Hospital (GB)
Publication Details
- Journal
- Organic Letters
- Published
- 2024-10-22
- DOI
- https://doi.org/10.1021/acs.orglett.4c03653
- Citations
- 6
- Primary Topic
- Catalytic C–H Functionalization Methods
- Type
- article
- Field-Weighted Citation Impact
- 1.50
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Hubei Province
- Wuhan Business University
- South-Central University for Nationalities