The Association Between Constipation and Positron Emission Tomography and Blood-Based Biomarkers in Older Cognitively Unimpaired Adults with Higher Amyloid-β Burden
Our data indicate that no/mild constipation may be associated with lower plasma t-Tau, p-Tau-181, and NfL as well as less Aβ and Tau burden in older CU adults with Aβ deposition. Improving constipation and being away from defecation disorders may help reduce the risk of AD development.
Authors
- Fang Xie (ORCID: https://orcid.org/0000-0003-2667-281X)
- Heling Chu (ORCID: https://orcid.org/0000-0001-8418-5775)
- Qihao Guo (ORCID: https://orcid.org/0000-0001-5079-8047)
- Chuyi Huang (ORCID: https://orcid.org/0000-0002-0326-8470)
Institutions
- Shanghai Jiao Tong University (CN)
- Fudan University (CN)
- Renji Hospital (CN)
- Shanghai Sixth People's Hospital (CN)
- Huashan Hospital (CN)
Publication Details
- Journal
- Neurology and Therapy
- Published
- 2024-10-22
- DOI
- https://doi.org/10.1007/s40120-024-00666-x
- Citations
- 2
- Primary Topic
- Diet and metabolism studies
- Type
- article
- Field-Weighted Citation Impact
- 0.65
Funders
- National Natural Science Foundation of China