IQGAP3 signalling mediates intratumoral functional heterogeneity to enhance malignant growth
IQGAP3 knockdown suppressed the RAS-TGFβ signalling crosstalk, leading to a significant reduction of the tumour microenvironment. In particular, IQGAP3 maintains functional heterogeneity of cancer cells to enhance malignant growth. IQGAP3 is thus a highly relevant therapy target in GC.
Authors
- Khine Nyein Myint (ORCID: https://orcid.org/0000-0002-9793-3303)
- Patrick Tan (ORCID: https://orcid.org/0000-0002-0179-8048)
- Junichi Matsuo (ORCID: https://orcid.org/0000-0002-2378-2370)
- Wei Peng Yong (ORCID: https://orcid.org/0000-0003-4404-3777)
- Daisuke Douchi (ORCID: https://orcid.org/0000-0003-4582-6589)
- Yoshiaki Ito (ORCID: https://orcid.org/0000-0002-9037-1184)
- Jung-Won Lee
- Mitsuhiro Shimura (ORCID: https://orcid.org/0000-0002-4147-8081)
- Linda Shyue Huey Chuang (ORCID: https://orcid.org/0000-0001-9078-9532)
- Nawaphat Jangphattananont (ORCID: https://orcid.org/0009-0009-9669-0459)
- Jimmy Bok Yan So (ORCID: https://orcid.org/0000-0002-9772-7905)
- ShuChin Pang
- Michiaki Unno (ORCID: https://orcid.org/0000-0002-2145-6416)
- Khay Guan Yeoh (ORCID: https://orcid.org/0000-0002-7802-4606)
- Supriya Srivastava (ORCID: https://orcid.org/0000-0002-6727-3076)
- Ming Teh (ORCID: https://orcid.org/0000-0001-6879-8678)
- Vivien Koh
- Aashiq Hussain
- Jasmine Jie Lin Tong
- Muhammad Bakhait Bin Rahmat
Institutions
- National University of Singapore (SG)
- Tohoku University (JP)
- National University Cancer Institute, Singapore (SG)
- Duke-NUS Medical School (SG)
- National University Health System (SG)
- Genome Institute of Singapore (SG)
Publication Details
- Journal
- Gut
- Published
- 2024-10-22
- DOI
- https://doi.org/10.1136/gutjnl-2023-330390
- Citations
- 11
- Primary Topic
- Genetic factors in colorectal cancer
- Type
- article
- Field-Weighted Citation Impact
- 4.67