The Analgesic and Side Effects of Tramadol Hydrochloride Immediate-Release and Extended-Release Tablets in Patients With Chronic Low Back Pain
This study shows the incidence of side effects following the administration of tramadol hydrochloride immediate-release and extended-release tablets. Regarding the breakdown of side effects, constipation, nausea, drowsiness, and dizziness were noted. Regarding pain evaluation, we found a significant reduction in the VAS scores for low back pain from baseline after four weeks of treatment, suggesting that tramadol hydrochloride immediate-release and extended-release tablets may provide excellent analgesic effects owing to their pharmacokinetic properties that ensure stable tramadol concentrations in the bloodstream.
Authors
- Kohei Okuyama (ORCID: https://orcid.org/0000-0001-7312-5670)
- Seiji Ohtori (ORCID: https://orcid.org/0000-0001-5738-6184)
- Takeshi Sainoh
- Hiroto Chikubu (ORCID: https://orcid.org/0009-0006-7711-1202)
- Kazuki Fujimoto (ORCID: https://orcid.org/0000-0002-3118-9366)
- Sumihisa Orita (ORCID: https://orcid.org/0000-0003-2676-5469)
- Kazuhide Inage (ORCID: https://orcid.org/0000-0003-0540-4613)
- Masaomi Yamashita (ORCID: https://orcid.org/0000-0002-6825-7182)
- Shuhei Ohyama
- Koki Abe (ORCID: https://orcid.org/0000-0003-2259-3989)
Institutions
- Chiba University (JP)
- Center for Global Health (US)
- Toyama University Hospital (JP)
- Funabashi Central Hospital (JP)
Publication Details
- Journal
- Cureus
- Published
- 2024-10-22
- DOI
- https://doi.org/10.7759/cureus.72124
- Citations
- 1
- Primary Topic
- Musculoskeletal pain and rehabilitation
- Type
- article
- Field-Weighted Citation Impact
- 0.45