ROCK Inhibitor Enhances Neurite Outgrowth In Vitro and Corneal Sensory Nerve Reinnervation In Vivo
These studies are the first to demonstrate expression of β4 integrin on trigeminal sensory neurons and preferential adhesion of neurons to the laminin-enriched matrices found in footprints deposited by human corneal limbal epithelial cells. In addition, we also document for the first time the positive impact of RI on neurite outgrowth in vitro and reinnervation in vivo.
Authors
- Beverly A. Karpinski
- Sonali Pal‐Ghosh
- Shyamali Datta
- Shelly Dimri
- Mary Ann Stepp (ORCID: https://orcid.org/0000-0001-5623-2538)
- Himani Datta-Majumdar
Institutions
- GW Medical Faculty Associates (US)
Publication Details
- Journal
- Investigative Ophthalmology & Visual Science
- Published
- 2024-10-22
- DOI
- https://doi.org/10.1167/iovs.65.12.31
- Citations
- 3
- Primary Topic
- Ocular Surface and Contact Lens
- Type
- article
- Field-Weighted Citation Impact
- 1.63
Funders
- National Institutes of Health
- National Eye Institute