Carcinoid heart disease in patients with advanced small-intestinal neuroendocrine tumors and carcinoid syndrome: a retrospective experience from two European referral centers
In our study population of SI-NET patients with CS, more than half had a refractory carcinoid syndrome (RCS) and one-quarter developed a CHD, with a negative impact on OS. Therefore, it is recommended to screen and monitor patients with CS for CHD, ideally with a combination of u5-HIAA, NT-proBNP values, and echocardiography at CS baseline, preferably in NET referral centers.
Authors
- Joakim Crona (ORCID: https://orcid.org/0000-0003-0677-4894)
- V. Bagnardi
- Nicola Fazio (ORCID: https://orcid.org/0000-0001-6869-0704)
- Daniela Maria Cardinale (ORCID: https://orcid.org/0000-0002-4038-8033)
- Samuele Frassoni (ORCID: https://orcid.org/0000-0002-4265-2627)
- Lovisa Falkman (ORCID: https://orcid.org/0009-0002-7290-8643)
- Giuseppe Badalamenti (ORCID: https://orcid.org/0000-0002-2478-8838)
- D. Tamayo (ORCID: https://orcid.org/0000-0002-2737-4577)
- Lorenzo Gervaso (ORCID: https://orcid.org/0000-0003-3313-8527)
- Laura Algeri
- D. Ciardiello
- C.A. Cella
- Francesca Spada (ORCID: https://orcid.org/0000-0003-3642-0798)
- S. Boselli
- Cristina Mazzon
- Maria Giulia Zampino (ORCID: https://orcid.org/0000-0001-5142-1778)
- Ashley Russo (ORCID: https://orcid.org/0009-0000-0637-8352)
- L. Benini (ORCID: https://orcid.org/0009-0009-0213-6538)
- Staffan Welin
- Marco Zanobini (ORCID: https://orcid.org/0000-0003-4400-0451)
Institutions
- Uppsala University Hospital (SE)
- Centro Cardiologico Monzino (IT)
- European Institute of Oncology (IT)
- University of Milano-Bicocca (IT)
- University of Palermo (IT)
Publication Details
- Journal
- ESMO Open
- Published
- 2024-10-22
- DOI
- https://doi.org/10.1016/j.esmoop.2024.103959
- Citations
- 8
- Primary Topic
- Neuroendocrine Tumor Research Advances
- Type
- article
- Field-Weighted Citation Impact
- 3.09