Fecal microbiota transplantation alters the proteomic landscape of inflammation in HIV: identifying bacterial drivers
Targeting the gut microbiome through FMT effectively decreased inflammatory proteins in PWH, with sustained effects. These findings suggest the potential of the microbiome as a therapeutic target to mitigate inflammation-related complications in this population, encouraging further research and development of microbiome-based interventions. Video Abstract.
Authors
- José A. Pérez‐Molina (ORCID: https://orcid.org/0000-0001-8735-4124)
- Laura Martín‐Pedraza (ORCID: https://orcid.org/0000-0003-3133-0662)
- María Jesús Vivancos (ORCID: https://orcid.org/0000-0002-9373-6011)
- Elena Moreno (ORCID: https://orcid.org/0000-0002-2301-4558)
- Laura Luna (ORCID: https://orcid.org/0000-0003-2373-8131)
- Alba Talavera-Rodríguez (ORCID: https://orcid.org/0000-0002-4696-8039)
- Jaime Huerta‐Cepas (ORCID: https://orcid.org/0000-0003-4195-5025)
- Sergio Serrano‐Villar (ORCID: https://orcid.org/0000-0002-5447-3554)
- Sara González-Bodí (ORCID: https://orcid.org/0000-0003-3178-2976)
- Fernando Dronda
- María José Gosalbes (ORCID: https://orcid.org/0000-0003-0460-1105)
- C. Vanesa Díaz-García (ORCID: https://orcid.org/0000-0001-7570-7113)
- Santiago Moreno (ORCID: https://orcid.org/0000-0002-2843-1094)
- Lucía Martín-Fernández
Institutions
- Universidad de Alcalá (ES)
- Instituto de Salud Carlos III (ES)
- Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (ES)
- Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria (ES)
- Instituto Ramón y Cajal de Investigación Sanitaria (ES)
- Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública (ES)
- Hospital Universitario Ramón y Cajal (ES)
- Centre for Plant Biotechnology and Genomics (ES)
- Universidad Politécnica de Madrid (ES)
Publication Details
- Journal
- Microbiome
- Published
- 2024-10-22
- DOI
- https://doi.org/10.1186/s40168-024-01919-5
- Citations
- 18
- Primary Topic
- Clostridium difficile and Clostridium perfringens research
- Type
- article
- Field-Weighted Citation Impact
- 7.00
Funders
- Gilead Sciences
- European Commission
- Fundación Española para la Ciencia y la Tecnología
- Sociedad Española de Enfermedades Infecciosas y Microbiología Clínica
- Instituto de Salud Carlos III
- European Regional Development Fund