Combining ERAP1 silencing and entinostat therapy to overcome resistance to cancer immunotherapy in neuroblastoma
These findings demonstrate that ERAP1 inhibition combined with HDACi entinostat treatment and PD-1 blockade remodels the immune landscape of a non-immunogenic tumor such as NB, making it responsive to checkpoint immunotherapy.
Authors
- Kamila Król (ORCID: https://orcid.org/0000-0002-0410-7513)
- Valentina Doria (ORCID: https://orcid.org/0000-0001-5963-0734)
- Doriana Fruci (ORCID: https://orcid.org/0000-0003-3388-7296)
- Valeria Lucarini (ORCID: https://orcid.org/0000-0002-3553-8818)
- Roberto Giovannoni (ORCID: https://orcid.org/0000-0002-7706-0672)
- Patrizia Tempora (ORCID: https://orcid.org/0000-0003-2587-6722)
- Silvia D’Amico (ORCID: https://orcid.org/0000-0002-9805-4589)
- Kirti Pandey (ORCID: https://orcid.org/0000-0003-0799-6376)
- Franco Locatelli (ORCID: https://orcid.org/0000-0002-7976-3654)
- Marco Pezzullo (ORCID: https://orcid.org/0000-0002-1353-6125)
- Gabriele Volpe
- Cristiano De Stefanis (ORCID: https://orcid.org/0000-0001-5898-9518)
- Maria Antonietta De Ioris (ORCID: https://orcid.org/0000-0002-2113-4505)
- Ombretta Melaiu (ORCID: https://orcid.org/0000-0001-7118-5186)
- Verena Damiani (ORCID: https://orcid.org/0000-0003-2833-841X)
- Ezio Giorda (ORCID: https://orcid.org/0000-0002-5875-832X)
- Shanzou Chung
- Marco Scarsella (ORCID: https://orcid.org/0000-0002-3386-9664)
- Anthony W. Purcell (ORCID: https://orcid.org/0000-0003-0532-8331)
- Paula Gragera (ORCID: https://orcid.org/0009-0007-5088-1757)
- Lorenzo De Angelis (ORCID: https://orcid.org/0000-0003-3830-5021)
- Valentina Scaldaferri (ORCID: https://orcid.org/0009-0001-5005-5910)
Institutions
- Università Cattolica del Sacro Cuore (IT)
- University of Pisa (IT)
- University of Rome Tor Vergata (IT)
- Australian Regenerative Medicine Institute (AU)
- Polo d’Innovazione di Genomica (IT)
- Bambino Gesù Children's Hospital (IT)
- Istituti di Ricovero e Cura a Carattere Scientifico (IT)
- Monash University (AU)
Publication Details
- Journal
- Journal of Experimental & Clinical Cancer Research
- Published
- 2024-10-22
- DOI
- https://doi.org/10.1186/s13046-024-03180-y
- Citations
- 15
- Primary Topic
- Neuroblastoma Research and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 5.54
Funders
- Institut Necker-Enfants Malades
- Australian Government
- European Commission
- Ministero della Salute
- Fondazione Umberto Veronesi
- Associazione Italiana per la Ricerca sul Cancro
- Horizon 2020 Framework Programme
- Medical Research Council
- National Health and Medical Research Council
- H2020 Marie Skłodowska-Curie Actions