Phenotyping <i>in vivo</i> chronic inflammation in multiple sclerosis by combined <sup>11</sup>C-PBR28 MR-PET and 7T susceptibility-weighted imaging
<sup>11</sup>C-PBR28 imaging reveals more active WM lesions than 7T PRL assessment. Although PRL and PET active lesion counts are related, neurological disability is better explained by PET whole active lesion volume.
Authors
- Alessandro Miscioscia (ORCID: https://orcid.org/0000-0001-7465-6246)
- Valeria Barletta (ORCID: https://orcid.org/0000-0003-0655-9406)
- Caterina Mainero (ORCID: https://orcid.org/0000-0003-3244-8507)
- Roberto Bomprezzi (ORCID: https://orcid.org/0000-0003-4009-0226)
- Ambica Mehndiratta
- Tobias Granberg (ORCID: https://orcid.org/0000-0001-6700-1022)
- Jacob A. Sloane (ORCID: https://orcid.org/0000-0003-0028-3031)
- Marco L. Loggia (ORCID: https://orcid.org/0000-0002-8026-5265)
- Elena Herranz (ORCID: https://orcid.org/0000-0001-7207-6811)
- Constantina A. Treaba (ORCID: https://orcid.org/0000-0001-8260-207X)
Institutions
- Beth Israel Deaconess Medical Center (US)
- Karolinska University Hospital (SE)
- Harvard University (US)
- University of Padua (IT)
- University of Massachusetts Chan Medical School (US)
- Karolinska Institutet (SE)
- Massachusetts General Hospital (US)
- Athinoula A. Martinos Center for Biomedical Imaging (US)
Publication Details
- Journal
- Multiple Sclerosis Journal
- Published
- 2024-10-22
- DOI
- https://doi.org/10.1177/13524585241284157
- Citations
- 7
- Primary Topic
- Multiple Sclerosis Research Studies
- Type
- article
- Field-Weighted Citation Impact
- 2.97
Funders
- U.S. Department of Defense
- National Multiple Sclerosis Society
- Biogen
- Celgene
- National Institutes of Health
- Genentech