Exosomal miR-1a-3p derived from glucocorticoid-stimulated M1 macrophages promotes the adipogenic differentiation of BMSCs in glucocorticoid-associated osteonecrosis of the femoral head by targeting Cebpz
We demonstrated that exosomes derived from GC-M1 macrophages disrupt the balance between osteogenic and adipogenic differentiation in BMSCs, contributing to the pathogenesis of GA-ONFH. Inhibiting miR-1a-3p expression, both in vitro and in vivo, significantly mitigates the preferential adipogenic differentiation of BMSCs, thus slowing the progression of GA-ONFH. These findings provide new insights into the regulatory mechanisms underlying GA-ONFH and highlight potential therapeutic targets for intervention.
Authors
- Min Nie (ORCID: https://orcid.org/0000-0001-7179-0044)
- Ping Duan (ORCID: https://orcid.org/0000-0001-7833-9651)
- Yan‐Xiao Ji (ORCID: https://orcid.org/0000-0002-3401-2427)
- Qing Yang (ORCID: https://orcid.org/0000-0002-5910-458X)
- Liming Xia (ORCID: https://orcid.org/0000-0001-8481-3380)
- Yan-Nan Cheng
- Yong-Le Yu
- Zhenyu Pan (ORCID: https://orcid.org/0000-0002-1272-6402)
Institutions
- Wuhan University (CN)
- Hubei Provincial Center for Disease Control and Prevention (CN)
- Zhongnan Hospital of Wuhan University (CN)
Publication Details
- Journal
- Journal of Nanobiotechnology
- Published
- 2024-10-22
- DOI
- https://doi.org/10.1186/s12951-024-02923-5
- Citations
- 10
- Primary Topic
- Bone and Joint Diseases
- Type
- article
- Field-Weighted Citation Impact
- 4.78
Funders
- National Natural Science Foundation of China
- Wuhan University
- Zhongnan Hospital of Wuhan University