GABAB modulate NF-κB/NLRP3 pathways in electroacupuncture prevention of depression in CUMS rats
Through the promotion of GABA<sub>B</sub> levels, regulation of synaptic plasticity within the LHb, and inhibition of NF-κB/NLRP3-mediated neuroinflammation in the same region, electroacupuncture at Shangxing and Fengfu acupoints demonstrates efficacy in mitigating depression-like behaviors induced by CUMS.
Authors
- Simin Yan
- Tiansheng Zhang (ORCID: https://orcid.org/0000-0002-8977-6117)
- Tao Tong
- Chongyao Hao
- Muhammad H. Shahzad (ORCID: https://orcid.org/0000-0003-0414-0345)
- Yizheng Li (ORCID: https://orcid.org/0000-0003-0865-3877)
- Xianjun Meng (ORCID: https://orcid.org/0000-0003-4609-9248)
- Jianguo Li (ORCID: https://orcid.org/0000-0002-2251-8308)
- Yao Dong (ORCID: https://orcid.org/0000-0001-8883-5384)
- Meng Li (ORCID: https://orcid.org/0000-0002-8320-5241)
- Zhongwen Li (ORCID: https://orcid.org/0000-0001-7187-5566)
- Jingxuan Li (ORCID: https://orcid.org/0000-0003-2504-837X)
- Junliang Shen
- Jingyu Zeng
- Zhuoran You
Institutions
- Longyan University (CN)
- Xiamen University (CN)
- First Affiliated Hospital of Xiamen University (CN)
- 174th hospital of the People's Liberation Army (CN)
- Xiamen University Malaysia (MY)
- Shanxi University of Traditional Chinese Medicine (CN)
- China Association of Acupuncture-Moxibustion (CN)
- Xiamen Chang Gung Hospital (CN)
- Shanxi Cardiovascular Hospital (CN)
Publication Details
- Journal
- Brain Research Bulletin
- Published
- 2024-10-22
- DOI
- https://doi.org/10.1016/j.brainresbull.2024.111108
- Citations
- 14
- Primary Topic
- Acupuncture Treatment Research Studies
- Type
- article
- Field-Weighted Citation Impact
- 10.03