Multiplex antimicrobial activities of the self-assembled amphiphilic polypeptide β nanofiber KF-5 against vaginal pathogens
KF-5 demonstrates significant potential as a safe and effective antimicrobial agent for treating vaginal infections. Its ability to disrupt microbial membranes while maintaining biocompatibility with human cells highlights its potential for clinical application. These findings provide a foundation for further development of KF-5 as a therapeutic option for combating drug-resistant infections.
Authors
- Jun Cao (ORCID: https://orcid.org/0000-0001-5298-9234)
- Haojue Wang (ORCID: https://orcid.org/0000-0002-9536-1946)
- Ling Fang (ORCID: https://orcid.org/0000-0003-2092-3681)
- Tiancheng Yang (ORCID: https://orcid.org/0000-0003-4868-0167)
Institutions
- Jiangsu Institute of Parasitic Diseases (CN)
- Zhongda Hospital Southeast University (CN)
- Wuxi People's Hospital (CN)
- Nanjing Medical University (CN)
Publication Details
- Journal
- Biology Direct
- Published
- 2024-10-22
- DOI
- https://doi.org/10.1186/s13062-024-00546-2
- Primary Topic
- Antimicrobial Peptides and Activities
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China