Aging and senescent fates of oligodendrocyte precursor cells in the mouse brain
Age-related changes in oligodendrocyte precursor cells (OPCs) contribute to white matter dysfunction. In aged mice, we hypothesized that myelin-dense fimbria OPCs possess niche-specific properties, compared to hippocampal OPCs. Aged fimbria OPCs were fewer, larger, and localized to neighboring microglia. We identified age-increased p16/Cdkn2a-expressing OPCs enriched for senescence-related pathways and distinct senescence signatures between hippocampus and fimbria. Aged brain OPC populations differ in microenvironment properties and responses to senescence-directed intervention.
Authors
- Marissa J. Schafer (ORCID: https://orcid.org/0000-0002-1470-1583)
- Chase M. Carver (ORCID: https://orcid.org/0000-0003-4002-2418)
- Sonia L. Rodriguez
- Xu Zhang (ORCID: https://orcid.org/0000-0002-9784-0481)
- Liguo Wang (ORCID: https://orcid.org/0000-0003-2072-4826)
- P. Gómez (ORCID: https://orcid.org/0000-0002-9505-9763)
Institutions
- Mayo Clinic (US)
- Mayo Clinic in Arizona (US)
- Mayo Clinic in Florida (US)
Publication Details
- Journal
- npj Aging
- Published
- 2024-10-22
- DOI
- https://doi.org/10.1038/s41514-024-00176-y
- Citations
- 16
- Primary Topic
- Neurogenesis and neuroplasticity mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 6.58
Funders
- National Institutes of Health
- National Institute on Aging