Phase II Study of Palbociclib in Patients with Tumors with CDK4 or CDK6 Amplification: Results from the NCI-MATCH ECOG-ACRIN Trial (EAY131) Subprotocol Z1C
Palbociclib showed limited activity in histology-agnostic CDK4- or CDK6-amplified tumors, although central nervous system tumors may be worthy of future investigation.
Authors
- Angela M. DeMichele (ORCID: https://orcid.org/0000-0003-1297-4251)
- Lyndsay N. Harris (ORCID: https://orcid.org/0000-0002-9774-6719)
- Keith T. Flaherty (ORCID: https://orcid.org/0000-0002-3402-0478)
- Peter James O'Dwyer (ORCID: https://orcid.org/0000-0002-9302-4073)
- Larry Rubinstein (ORCID: https://orcid.org/0000-0002-9720-9737)
- David R. Patton (ORCID: https://orcid.org/0000-0003-3855-0166)
- Lisa M. McShane (ORCID: https://orcid.org/0000-0001-8195-3206)
- Mark H. O’Hara (ORCID: https://orcid.org/0000-0003-2751-6122)
- Mark A. Dickson (ORCID: https://orcid.org/0000-0003-2764-751X)
- Carlos L. Arteaga (ORCID: https://orcid.org/0000-0003-0870-9586)
- Alice P. Chen (ORCID: https://orcid.org/0000-0002-1426-853X)
- Richard Piekarz (ORCID: https://orcid.org/0000-0002-3591-7893)
- Barbara A. Conley (ORCID: https://orcid.org/0000-0002-1445-1684)
- James V. Tricoli (ORCID: https://orcid.org/0000-0003-3975-8516)
- Robert J. Gray (ORCID: https://orcid.org/0000-0002-5724-4917)
- Stanley R. Hamilton (ORCID: https://orcid.org/0000-0002-8331-1052)
- Opeyemi A. Jegede (ORCID: https://orcid.org/0000-0003-1763-8214)
- P. Mickey Williams (ORCID: https://orcid.org/0000-0002-3309-5988)
- Adedayo A. Onitilo (ORCID: https://orcid.org/0000-0001-9185-0606)
- Victoria Wang (ORCID: https://orcid.org/0000-0003-4079-5576)
Institutions
- National Institutes of Health (US)
- City Of Hope National Medical Center (US)
- Memorial Sloan Kettering Cancer Center (US)
- Cornell University (US)
- Kettering University (US)
- Massachusetts General Hospital (US)
- ECOG-ACRIN Cancer Research Group (US)
- City of Hope (US)
- Marshfield Clinic Weston Center (US)
- Dana-Farber Cancer Institute (US)
- National Cancer Institute (UA)
- Frederick National Laboratory for Cancer Research (US)
- National Cancer Institute (MY)
- National Cancer Institute (US)
- University of Pennsylvania (US)
- The University of Texas Southwestern Medical Center (US)
Publication Details
- Journal
- Clinical Cancer Research
- Published
- 2024-10-22
- DOI
- https://doi.org/10.1158/1078-0432.ccr-24-0036
- Citations
- 4
- Primary Topic
- Advanced Breast Cancer Therapies
- Type
- article
- Field-Weighted Citation Impact
- 1.68
Funders
- American College of Radiology Imaging Network
- Margaret A. Cargill Foundation
- ECOG-ACRIN Cancer Research Group
- National Institutes of Health
- National Cancer Institute