Metabolic Tumor Volume Assessed by 18F FDG–PET CT Scan as a Predictive Biomarker for Immune Checkpoint Blockers in Advanced NSCLC and Its Biological Correlates
Our analysis indicates high tMTV is linked to an increase in systemic inflammation, specific cytokines production, and chromosomal instability. tMTV may serve as one of the biomarkers to select the best upfront strategy in patients with PD-L1-positive advanced NSCLC.
Authors
- Francesco Passiglia (ORCID: https://orcid.org/0000-0002-0244-5738)
- Patricia Kannouche (ORCID: https://orcid.org/0000-0002-6050-3457)
- Lizza Hendriks (ORCID: https://orcid.org/0000-0002-3521-2535)
- Silvia Novello (ORCID: https://orcid.org/0000-0001-7653-9748)
- Isabelle Monnet (ORCID: https://orcid.org/0000-0003-3279-9569)
- Camilo Garcia (ORCID: https://orcid.org/0000-0002-4201-1862)
- Hester A. Gietema (ORCID: https://orcid.org/0000-0001-6077-1446)
- Cristina Mitea (ORCID: https://orcid.org/0000-0001-5885-957X)
- Valentina Ambrosini (ORCID: https://orcid.org/0000-0002-5008-5351)
- M.A. Bettaieb (ORCID: https://orcid.org/0009-0004-4458-8026)
- Wael Zrafi (ORCID: https://orcid.org/0000-0003-4289-6821)
- Benjamin Besse (ORCID: https://orcid.org/0000-0001-5090-8189)
- Kristi Beshiri (ORCID: https://orcid.org/0000-0001-5776-9070)
- Safiye Dursun (ORCID: https://orcid.org/0000-0002-8723-9801)
- Monica Velasco-Nuño (ORCID: https://orcid.org/0000-0002-7449-5478)
- David Planchard (ORCID: https://orcid.org/0000-0002-1565-8310)
- G. Bonardel (ORCID: https://orcid.org/0000-0001-5180-2167)
- Nathalie Chaput (ORCID: https://orcid.org/0000-0003-3968-8669)
- Aloÿse Fourquet (ORCID: https://orcid.org/0000-0002-9013-5085)
- Andrea Ardizzoni (ORCID: https://orcid.org/0000-0003-2678-0714)
- Matteo Bauckneht (ORCID: https://orcid.org/0000-0002-1937-9116)
- Marie Naigeon (ORCID: https://orcid.org/0000-0002-2996-7720)
- Daniel Gautheret (ORCID: https://orcid.org/0000-0002-1508-8469)
- Nicole Conci (ORCID: https://orcid.org/0000-0002-8438-7489)
- Valérie Lacroix (ORCID: https://orcid.org/0000-0003-4600-2426)
- Désirèe Deandreis (ORCID: https://orcid.org/0000-0002-3817-6648)
- Filippo Gustavo Dall’Olio (ORCID: https://orcid.org/0000-0003-0903-6109)
- Lisa Derosa (ORCID: https://orcid.org/0000-0003-0527-2964)
- Eugenia Cella (ORCID: https://orcid.org/0009-0005-9507-8357)
- V. Gounant (ORCID: https://orcid.org/0000-0002-9473-1247)
- José Carlos Benítez (ORCID: https://orcid.org/0000-0002-8776-9132)
- Frank Aboubakar Nana (ORCID: https://orcid.org/0000-0002-6205-5053)
- Mihaela D. Aldea (ORCID: https://orcid.org/0000-0001-7685-051X)
- Jordi Remón (ORCID: https://orcid.org/0000-0002-9462-875X)
- François‐Xavier Danlos (ORCID: https://orcid.org/0000-0003-1880-064X)
- Antoîne Italiano (ORCID: https://orcid.org/0000-0002-8540-5351)
- Gérard Zalcman
- Bastien Job (ORCID: https://orcid.org/0000-0002-2720-7664)
- Guido Rovera (ORCID: https://orcid.org/0000-0003-1839-0206)
- Aurélien Marabelle (ORCID: https://orcid.org/0000-0002-5816-3019)
- Giulia Argalia (ORCID: https://orcid.org/0000-0003-2597-4146)
- Valerio Iebba (ORCID: https://orcid.org/0000-0002-0716-306X)
- Marco Tagliamento (ORCID: https://orcid.org/0000-0001-7461-023X)
- Laurence Zitvogel (ORCID: https://orcid.org/0000-0003-1596-0998)
- Damien Vasseur (ORCID: https://orcid.org/0000-0001-8787-1498)
- Céline Namour
- Fabrice Barlési (ORCID: https://orcid.org/0000-0001-5793-3539)
- Vincenzo Arena (ORCID: https://orcid.org/0000-0001-7363-0781)
- Véronique Roelants (ORCID: https://orcid.org/0000-0003-4278-028X)
- J. Freitas (ORCID: https://orcid.org/0000-0002-6708-7345)
- Delphine Hoton
Institutions
- Université Claude Bernard Lyon 1 (FR)
- Centre National de la Recherche Scientifique (FR)
- Cliniques Universitaires Saint-Luc (BE)
- University of Trieste (IT)
- Inserm (FR)
- Université Paris Cité (FR)
- Université Paris-Saclay (FR)
- Maastricht University Medical Centre (NL)
- Institut Gustave Roussy (FR)
- Maastricht University (NL)
- La Ligue Contre le Cancer (FR)
- IRCCS Azienda Ospedliero-Universitaria di Bologna Policlinico di Sant'Orsola (IT)
- Assistance Publique – Hôpitaux de Paris (FR)
- Azienda USL di Bologna (IT)
- Laboratoire d'études sur les monothéismes (FR)
- HM Hospitales (ES)
- Department of Medical Sciences (BY)
- Institut Bergonié (FR)
- Delfos Hospital (ES)
- Hôpital Bichat-Claude-Bernard (FR)
- Ospedale Policlinico San Martino (IT)
- Centre Cardiologique du Nord (FR)
- Ospedale San Luigi Gonzaga (IT)
- Hospital Clínico Universitario Virgen de la Victoria (ES)
- Hôpital Intercommunal de Créteil (FR)
- Bicêtre Hospital (FR)
- Instituto de Investigación Biomédica de Málaga (ES)
- University of Turin (IT)
- Universidad de Málaga (ES)
- University of Genoa (IT)
- University of Bologna (IT)
Publication Details
- Journal
- Clinical Cancer Research
- Published
- 2024-10-22
- DOI
- https://doi.org/10.1158/1078-0432.ccr-24-1993
- Citations
- 12
- Primary Topic
- Cancer Immunotherapy and Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 3.39